Anterior Segment- Optical Coherence Tomography as Early Biomarker in Diabetic Retinopathy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Diabetes Mellitus
- Sponsor
- Federico II University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- The measurements of corneal features in patients with type 2 diabetes mellitus, using anterior segment-optical coherence tomography
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This study evaluates the corneal features using anterior segment - optical coherence tomography in patients affected by type 2 diabetes mellitus
Detailed Description
To investigate the potential role of anterior segment-optical coherence tomography (AS-OCT) in identifying the corneal changes (in particular in total corneal, epithelial and stromal thicknesses) in patients affected by type 2 diabetes mellitus, without signs of diabetic retinopathy at fundus examination. The AS-OCT could represents a valid early biomarker in these patients.
Investigators
Gilda Cennamo
Principal Investigator
Federico II University
Eligibility Criteria
Inclusion Criteria
- •age older than 50 years
- •diagnosis of previous type 2 diabetes mellitus
- •absence of signs of diabetic retinopathy
- •absence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
- •absence of significant lens opacities, low-quality OCT and OCT-A images
Exclusion Criteria
- •age younger than 50 years
- •absence of previous diagnosis of type 2 diabetes mellitus
- •presence of signs of diabetic retinopathy
- •presence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
- •presence of significant lens opacities, low-quality OCT and OCT-A images.
Outcomes
Primary Outcomes
The measurements of corneal features in patients with type 2 diabetes mellitus, using anterior segment-optical coherence tomography
Time Frame: twelve months
The parameters analyzed by anterior segment-optical coherence tomography angiography were: total corneal, epithelial and stromal thicknesses