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Clinical Trials/NCT04969640
NCT04969640CompletedNot Applicable

Role of Anterior Segment Optical Coherence Tomography in Staging and Evaluation of Treatment Response in Infectious Keratitis

Minia University1 site in 1 country23 target enrollmentStarted: July 1, 2021Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
23
Locations
1
Primary Endpoint
width of lesion on optical coherence tomography
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

To evaluate the role of anterior segment optical coherence tomography in follow up of infectious keratitis and assessment of response to treatment.

Detailed Description

50 patients with proven infectious keratitis clinically will be included in the study.

The following will be performed for all patients in initial visit and follow up:

  • Slit lamp examination and photography.
  • Visual acuity assessment.
  • Anterior segment optical coherence tomography.
  1. The central corneal thickness (CCT) (extracted from pachymetry map),
  2. Minimal corneal thickness (MCT) (extracted from pachymetry map)
  3. Corneal thickness at the site of the lesion (CTL) (extracted from pachymetry map or the sum of STL+ CETL)
  4. Stromal thickness at the center of the lesion (STL) stromal lesion (extracted from stromal map)
  5. Corneal epithelial thickness over the stromal lesion (CETL) at the center of the lesion (extracted from epithelial map)

Study Design

Study Type
Observational
Observational Model
Other
Time Perspective
Prospective

Eligibility Criteria

Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Any case with infectious keratitis (any age) either received medical treatment or not, attending to our department will be included in the study.

Exclusion Criteria

  • •Cases with healed infectious keratitis.
  • •Cases presented from the start with severe corneal affection and melting.

Outcomes

Primary Outcomes

width of lesion on optical coherence tomography

Time Frame: 1 month

width of infiltration in microns

criteria of lesion on optical coherence tomography

Time Frame: 1 month

Localiztion, depth of infiltration area in microns

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
Minia University
Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Ahemd Abdelghany

Assistant professor

Minia University

Study Sites (1)

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