Anterior Segment Optical Coherence Tomography Study of the Tear Film and Cornea in Thyroid Eye Diseases.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- Tear Meniscus Depth (TMD):
研究概览
简要总结
use the anterior segment optical coherence tomography (AS-OCT) to evaluate the tear meniscus parameters, total corneal thickness (CT), and epithelial thickness in active and inactive thyroid eye diseases (TED) patients and compare them with age-matched controls.
详细描述
A prospective case-control clinical study. The study subjects were divided into 3 groups, group 1 of inactive thyroid patients, group 2 of active thyroid patients, and group 3 of healthy controls. The AS-OCT was used to measure lower tear meniscus parameters (tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA)), total CT and epithelial thickness
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The inclusion criteria were patients with thyroid disorders with age between 20 to 60 years with no ocular manifestations
排除标准
- •being younger than 20 or older than 60, presence of systemic diseases as diabetes mellitus (DM) and autoimmune diseases as rheumatoid arthritis (RA) that may cause dry eye, previous ocular surgery, use of contact lenses, smokers, pregnant women, and breastfeeding women.
结局指标
主要结局
Tear Meniscus Depth (TMD):
时间窗: through study completion, an average of 6 months
represented as the distance between the center of the upper boundary of the tear meniscus and the point at the bottom boundary where the cornea meets the eyelid
Tear Meniscus Height
时间窗: through study completion, an average of 6 months
represented by a line joining the points corresponding to the upper corneo-meniscus junction to the lower eyelid-meniscus junction
Tear Meniscus Area (TMA)
时间窗: through study completion, an average of 6 months
triangular area formed by the corneal anterior boundary, anterior boundary of the lower eyelid and anterior borderline of the tear meniscus
次要结局
未报告次要终点
研究者
Mohamed Salah
Dr Mohamed Salah
Minia University