Anterior Segment Optical Coherence Tomography Study of the Tear Film and Cornea in Thyroid Eye Diseases.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Thyroid Eye Disease
- Sponsor
- Minia University
- Enrollment
- 70
- Locations
- 2
- Primary Endpoint
- Tear Meniscus Depth (TMD):
- Last Updated
- 4 years ago
Overview
Brief Summary
use the anterior segment optical coherence tomography (AS-OCT) to evaluate the tear meniscus parameters, total corneal thickness (CT), and epithelial thickness in active and inactive thyroid eye diseases (TED) patients and compare them with age-matched controls.
Detailed Description
A prospective case-control clinical study. The study subjects were divided into 3 groups, group 1 of inactive thyroid patients, group 2 of active thyroid patients, and group 3 of healthy controls. The AS-OCT was used to measure lower tear meniscus parameters (tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA)), total CT and epithelial thickness
Investigators
Mohamed Salah
Dr Mohamed Salah
Minia University
Eligibility Criteria
Inclusion Criteria
- •The inclusion criteria were patients with thyroid disorders with age between 20 to 60 years with no ocular manifestations
Exclusion Criteria
- •being younger than 20 or older than 60, presence of systemic diseases as diabetes mellitus (DM) and autoimmune diseases as rheumatoid arthritis (RA) that may cause dry eye, previous ocular surgery, use of contact lenses, smokers, pregnant women, and breastfeeding women.
Outcomes
Primary Outcomes
Tear Meniscus Depth (TMD):
Time Frame: through study completion, an average of 6 months
represented as the distance between the center of the upper boundary of the tear meniscus and the point at the bottom boundary where the cornea meets the eyelid
Tear Meniscus Height
Time Frame: through study completion, an average of 6 months
represented by a line joining the points corresponding to the upper corneo-meniscus junction to the lower eyelid-meniscus junction
Tear Meniscus Area (TMA)
Time Frame: through study completion, an average of 6 months
triangular area formed by the corneal anterior boundary, anterior boundary of the lower eyelid and anterior borderline of the tear meniscus