Use of Peppermint Oil During Screening Colonoscopy to Improve Visibility

Not Applicable

Completed

• Conditions: Enhancement of the ADR During Colonoscopy
• Interventions: Other: Distilled water; Other: Peppermint Oil

• Registration Number: NCT03286764
• Lead Sponsor: Mayo Clinic

Brief Summary

The investigators hypothesize that spraying peppermint oil containing L-menthol onto the colonic mucosa during colonoscopy will relax smooth muscle allowing better colonic visualization.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-11
• Study First Submitted: 2017-09-15
• Study First Submitted QC: 2017-09-15
• Study First Posted: 2017-09-18
• Primary Completion: 2019-09-10
• Study Completion: 2019-09-10
• Status Verified: 2020-04
• Last Update Submitted: 2020-04-02
• Last Update Posted: 2020-04-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• Screening colonoscopy
• Age 50 years and older
• Able to give consent

Exclusion Criteria

• No consent obtained or adult lacking capacity to consent
• Do not reach cecum on colonoscopy
• Renal impairment (defined as CrCl <30 ml/min)
• Allergy to study peppermint oil solution
• History of colon resection
• Inflammatory bowel disease
• Known colorectal neoplasia
• Non-correctable coagulopathy
• Pregnancy or lactating
• Prisoners

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Distilled water	Distilled water spray as a placebo during Colonoscopy
Peppermint Oil	Peppermint Oil	Peppermint Oil spray during Colonoscopy

Primary Outcome Measures

Name	Time	Method
Determination of Adenoma Detection Rate during Colonoscopy Procedure	2 hours

Trial Locations

Locations (1)

Mayo Clinic in Arizona; 🇺🇸 Scottsdale, Arizona, United States