SitzMARK Evaluation of Reproducibility

Completed

• Conditions: diabetes; 10017943; 10018424

• Registration Number: NL-OMON42885
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Male obese subjects with metabolic syndrome (n<=10): 18 to 70 years-old; body mass index (BMI) 30kg/m2 or above with at least 3 out of 5 NCEP metabolic syndrome criteria (fasting plasma glucose * 5.6 mmol/l, triglycerides * 1.7 mmol/l, waist-circumference > 102 cm, HDL-cholesterol < 1.03 mmol/l, blood pressure * 130/85 mmHg). Patients should be able to give informed consent and be on a stable diet.;Healthy control subjects: 18-69 jr oud, BMI 18,5-25m²/kg. 0/5 NCEP criteria for metabolic syndrome.

Exclusion Criteria

Cholecystectomy, use of medication including PPI and antibiotics past three months, (expected) change of diet, episode of diarrhea during study period. irritable bowel syndrome-like complaints.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>intestinal transit time measured by SITZMARK-method</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>inflammatory parameters and gut microbiota composition</p><br>