Effect of Using Different Varnishes on Dentin Hypersensitivity; Na Fluoride and Nano-silver Fluoride

Not Applicable

• Conditions: Dentin Hypersensitivity
• Interventions: Behavioral: concocted nano-silver fluoride; Behavioral: Citrine 5 % sodium fluoride

• Registration Number: NCT04731766
• Lead Sponsor: Nayera Hassanien Mohamed

Brief Summary

2 different varnishes will be used to test their effectiveness in controlling teeth hypersensitivity in adult patient.

Detailed Description

In-vivo part:

Each varnish will be applied separately on different teeth according to the manufacturer's instructions and the VAS will be measured according to a specific timeline: T0 (baseline, before application of varnish), T1 (1 week after application), T2 (4 weeks after application) and T3 (4 weeks after application).

In-situ part:

Dentin specimen will be prepared from extracted teeth from the orthodontic department in our college, sterilized and prepared.

it will be bonded to an orthodontic wire and bonded to upper first molar. Dentinal occlusion will be measured using scanning electron microscope following the same timeline.

Study Timeline

• Study First Submitted: 2020-10-06
• Status Verified: 2021-01
• Study First Submitted QC: 2021-01-29
• Last Update Submitted: 2021-01-29
• Study First Posted: 2021-02-01
• Last Update Posted: 2021-02-01
• Study Start: 2021-11-01
• Primary Completion: 2022-01-01
• Study Completion: 2022-01-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

• Patients consulting in one of the Qasr Einy, faculty of dentistry outpatient clinics.
• Males or females.
• Patient's age range 25-50 years.
• Patients complaining of hypersensitive areas on facial surfaces of the teeth (incisors, cuspids, bi-cuspids, and first molars with exposed cervical dentine) with teeth scoring Bpain (VAS score: greater than or equal to 3) during application of stimulus (airblast and tactile sensitivity test).
• Tooth with exposed root surface, complaining from hypersensitivity (VAS score; greater than or equal to 3).
• Patients accept the 2-months follow-up period.
• Provide informed consent.

Exclusion Criteria

• • Patients participating in another dental study that may alter the results of this study.

  • A medical condition that could hinder the accuracy of pain reporting (e.g., pain disorders).
  • Any chronic medical condition that requires the regular use of anti-inflammatory pain medications.
  • Patients used or applied a desensitizing varnish within the last four weeks.
  • Patients with dental problems; chipped teeth, defective restorations, fractured Un-displaced cuspids or deep dental caries.
  • Lack of patient's approval and compliance.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
concocuted Nano-silver fluoride	concocted nano-silver fluoride	Nano-silver fluoride (NSF) is a laboratory synthesized solution
Citrine 5% Sodium Fluoride	Citrine 5 % sodium fluoride	It was developed to prolong the contact between the tooth surface and fluoride to increase the resistance against caries attack and manage tooth hypersensitivity; the active ingredient of fluoride varnish is mostly 5% sodium fluoride.

Primary Outcome Measures

Name	Time	Method
change in dentin Hypersensitivity	1 week, 4 weeks & 8 weeks	Visual Analogue Scale (VAS) will be used; 0 is no pain and 10 is severe pain. Pictures are added to the same, as well as colors to guide the patient during selection of pain severity.

Secondary Outcome Measures

Name	Time	Method
change in dentinal Tubule Occlusion	1 week, 4 weeks * 8 weeks	the dentinal tubule occlusion of citrine 5% sodium fluoride and the dentinal tubule occlusion of nano-silver fluoride for treatment of dentin hypersensitivity and compare them together