Efficacy of tranexamic acid in reducing blood loss in patients with placenta accrete spectrum

Phase 2

Conditions: Placenta accrete spectrum.
Placenta accreta
O43.21

Registration Number: IRCT20201003048909N1

Lead Sponsor: Ahvaz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 23

Inclusion Criteria

Age over 18 years
Diagnosis of placenta accrete spectrum syndrome on ultrasound
Singleton pregnancy
Cesarean section or cesarean section hysterectomy
Patient consent to participate in the study

Exclusion Criteria

History of cardiovascular diseases including coronary artery disease, myocardial infarction, severe arrhythmias, and congestive heart failure
history of the bleeding disorder including antiphospholipid syndrome (APS)
liver and kidney disease
known coagulation disorders
anemia preoperatively (hemoglobin level < 8 mg/dl)
history of preeclampsia or eclampsia in the current pregnancy
contraindication to TXA use (history of TXA allergy, venous thromboembolism, active thrombolytic diseases, acquired color vision disorders, history of seizure, pre-known hematuria, and renal failure

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Amount of estimated blood loss (EBL). Timepoint: Before and after surgery. Method of measurement: CC blood lost.;Complications during and after delivery. Timepoint: Evaluating the patient during and after delivery. Method of measurement: Incidence of complications during and after delivery such as rupture of the bowel, need for hysterectomy, hypogastric ligation, need for laparotomy, and rupture of the bladder.

Secondary Outcome Measures

Name	Time	Method
eed to blood products transfusion. Timepoint: during the surgery and the first 24 h after delivery. Method of measurement: Amount of received PRBCs, amount of received platelets, and amount of received FFP.;Duration of hospitalization. Timepoint: Number of hospitalization days after delivery. Method of measurement: Number of hospitalization days.