A Safety and Tolerability Study of Assisted and Self-Administered Subcutaneous (SC) Herceptin (Trastuzumab) as Adjuvant Therapy in Early Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer

Phase 3

Completed

• Conditions: Breast Neoplasms
• Interventions: Drug: Herceptin

• Registration Number: NCT01566721
• Lead Sponsor: Hoffmann-La Roche

Brief Summary

This multicenter, two-cohort, non-randomized, open-label study will evaluate the safety and tolerability of assisted and self-administered SC Herceptin as adjuvant therapy in participants with early HER2-positive breast cancer following tumor excision. Participants will receive Herceptin 600 milligrams (mg) SC every 3 weeks for 18 cycles, either by an assisted administration using a conventional syringe and needle/vial formulation (Cohort A) or with assisted and self-administration using a single-use injection device (SID) in selected participants (Cohort B).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-03-22
• Study First Submitted QC: 2012-03-27
• Study First Posted: 2012-03-29
• Study Start: 2012-05-17
• Primary Completion: 2015-03-10
• Results First Submitted: 2017-03-06
• Results First Submitted QC: 2017-03-06
• Results First Posted: 2017-04-18
• Study Completion: 2020-02-19
• Status Verified: 2021-04
• Last Update Submitted: 2021-04-26
• Last Update Posted: 2021-04-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2577

Inclusion Criteria

• Histologically confirmed early invasive HER2-positive carcinoma of the breast with no evidence of residual, locally recurrent, or metastatic disease and defined as clinical Stage I to IIIC that is eligible for treatment with Herceptin
• Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
• Screening left ventricular ejection fraction (LVEF) greater than or equal to (≥) 55%

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Exclusion Criteria

• Previous neoadjuvant or adjuvant breast cancer treatment with an approved or investigational anti-HER2 agent
• History of other malignancy except for curatively treated carcinoma in situ of the cervix, basal cell carcinoma, or curatively treated malignancies (other than breast cancer) where the participant has been disease-free for at least 5 years
• Past history of ductal carcinoma in situ treated with any systemic therapy or with radiation therapy to the ipsilateral breast where invasive cancer subsequently developed
• Metastatic disease
• Inadequate bone marrow, hepatic, or renal function
• Serious cardiac or cardiovascular disease including uncontrolled hypertension or history of hypertensive crisis or hypertensive encephalopathy
• History of severe allergic or immunological reactions, such as difficult-to-control asthma
• Pregnant or lactating women

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cohort A: SC Herceptin by Needle/Syringe	Herceptin	Participants will receive SC Herceptin by an assisted administration using a conventional syringe and needle/vial formulation.
Cohort B: SC Herceptin by SID	Herceptin	Participants will receive SC Herceptin with assisted and/or self-administered use of an SID. The first administration will be performed by a trained healthcare professional. If well tolerated and the participant is willing and judged competent to perform self-administration, subsequent administration of SC Herceptin may be performed by the participant.

Primary Outcome Measures

Name	Time	Method
Number of Herceptin Cycles Received	From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)	Participants were planned to receive a total of 18 cycles of SC Herceptin. The median number of cycles actually received was reported.
Percentage of Participants With a Grade 3 or Higher AE During the Treatment Period	From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)	Participants were planned to receive a total of 18 cycles of SC Herceptin. An AE was defined as any untoward medical occurrence in a participant administered SC Herceptin. Examples included unfavorable/unintended signs and symptoms, new or exacerbated disease, recurrence of intermittent condition, deterioration in laboratory value or other clinical test, or adverse procedure-related events. AEs were graded according to National Cancer Institute Common Terminology Criteria Version 4.0. Grade 3 AEs were those considered severe or medically significant but not immediately life-threatening. Grade 4 AEs were those considered life-threatening and/or for which urgent intervention was indicated. Grade 5 AEs were those resulting in death. The percentage of participants with a Grade 3 or higher (i.e., Grade 3 to 5) AE during the treatment period was reported.
Percentage of Participants by Total Number of Herceptin Cycles Received	From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)	Participants were planned to receive a total of 18 cycles of SC Herceptin. The percentage of participants was reported by the total number of cycles actually received. Because the data are presented non-cumulatively, this table reflects participant distribution by the highest number of cycles received.
Percentage of Participants Who Received Concomitant Cancer Therapy	From Baseline to data cutoff of 10 March 2015 (up to approximately 3 years)	Concomitant cancer treatment included chemotherapy, radiotherapy, and hormone therapy administered during the study. The percentage of participants who received any of these concomitant therapies was reported.
Percentage of Participants Who Received Concomitant Non-Cancer Therapy	From Baseline to data cutoff of 10 March 2015 (up to approximately 3 years)	Concomitant non-cancer treatment included any pharmacologic interventions administered during the study other than chemotherapy, radiotherapy, or hormone therapy. The percentage of participants who received any concomitant non-cancer therapies was reported.
Percentage of Participants With At Least 1 Adverse Event (AE) During the Treatment Period	From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)	Participants were planned to receive a total of 18 cycles of SC Herceptin. An AE was defined as any untoward medical occurrence in a participant administered SC Herceptin. Examples included unfavorable/unintended signs and symptoms, new or exacerbated disease, recurrence of intermittent condition, deterioration in laboratory value or other clinical test, or adverse procedure-related events. The percentage of participants with at least 1 AE during the treatment period (regardless of severity or seriousness) was reported.
Percentage of Participants With Treatment Interruption Due to an AE	From Day 1 up to 19 cycles (cycle length 3 weeks) (approximately 1 year)	Participants were planned to receive a total of 18 cycles of SC Herceptin. An AE was defined as any untoward medical occurrence in a participant administered SC Herceptin. Examples included unfavorable/unintended signs and symptoms, new or exacerbated disease, recurrence of intermittent condition, deterioration in laboratory value or other clinical test, or adverse procedure-related events. The percentage of participants with SC Herceptin treatment interrupted to assess or treat AEs was reported.

Secondary Outcome Measures

Name	Time	Method
Percentage of Participants Who Died During the Safety Follow-up Period	From Baseline to Time of Event, Safety Follow-Up Period (Up to 6 Years)	The percentage of participants who died from any cause was reported during the safety follow-up period.
Percentage of Participants Who Died by Data Cutoff of 10 March 2015	From Baseline to time of event (maximum follow-up approximately 3 years as of data cutoff of 10 March 2015)	The percentage of participants who died from any cause was reported.
Disease-Free Survival Rate	From Baseline to time of event (up to approximately 8 years)	DFS is defined as the time from first dose of SC Herceptin to the first event of local, regional or distant recurrence, contralateral invasive breast cancer (including ipsilateral ductal carcinoma in situ) or death due to any cause.; Time from the date of first dose to any DFS event was expressed in Kaplan-Meier survival probability estimates. Patients without an event will be censored at the last assessment date.
Overall Survival Rate	From Baseline to Time of Event (Up to Approximately 6 Years)	Overall survival was defined as the time from randomization to death from any cause.; Time from the date of randomization to the date of death was expressed in Kaplan-Meier survival probability estimates. Patients without an event will be censored at the last assessment date.
Percentage of Participants by Item Response to SID Satisfaction Questionnaire	Cycle 4 (cycle length 3 weeks) and last safety follow-up (LSFU) (approximately 1 year)	The SID satisfaction questionnaire was administered twice during the study and asked participants to respond to five statements using a Likert scale from "Strongly Disagree" to "Strongly Agree". Questionnaire items were as follows: "I felt comfortable injecting the study drug by myself" (Comfortable), "The SID was convenient and easy to use" (Easy to Use), "I am confident giving myself an injection in the thigh with the SID" (Confident), "Taking all things into account I find self-administration using the SID satisfactory" (Satisfactory), "If given the opportunity I would choose to continue self-injecting the study drug using the SID in the future" (Continue). Participants could only select one response per questionnaire item. There was no calculation of any score, but rather, descriptive summaries were generated by item response. The percentage of participants was reported by the response given for each item on the SID satisfaction questionnaire.

Trial Locations

Locations (437)

Hospital Metropolitano de Santiago; 🇩🇴 Santiago, Dominican Republic

Clinique Tivoli; Sce Radiotherapie; 🇫🇷 Bordeaux, France

Solca Guayaquil- Sociedad de Lucha Contra El Cáncer; Oncology; 🇪🇨 Guayaquil, Ecuador

Fakultní nemocnice Olomouc; 🇨🇿 Olomouc, Czechia

Nci; Oncology Dept; 🇪🇬 Cairo, Egypt

Clínica Imbanaco; Oncology; 🇨🇴 Cali, Colombia

Alexandria Uni ; Medical Oncology; 🇪🇬 Alexandria, Egypt

Ch De Fleyriat; Pneumologie 1; 🇫🇷 Bourg En Bresse, France

Centre Georges-François Lecler; Ctr de Lutte Contre le Canc; 🇫🇷 Dijon, France

Masarykův onkologický ústav; Klinika komplexní onkologické péče; 🇨🇿 Brno, Czechia

Instituto de Cáncer SOLCA Cuenca; Oncología; 🇪🇨 Cuenca, Ecuador

Clinical Hospital Osijek; Dept For Oncology & Radiotherapy; 🇭🇷 Osijek, Croatia

HOPITAL JEAN MINJOZ; Oncologie; 🇫🇷 Besancon, France

Polyclinique Bordeaux Nord Aquitaine; Chimiotherapie Radiotherapie; 🇫🇷 Bordeaux, France

Ch De La Dracenie; Hopital De Jour; 🇫🇷 Draguignan, France

Hospital Oncologia; Oncology; 🇸🇻 Salvador, El Salvador

Gemeinschaftspraxis Dr. Bueckner und Dr. Nueckel; 🇩🇪 Bochum, Germany

Hopital Augustin Morvan; Federation De Cancerologie; 🇫🇷 Brest, France

Elisabeth-Krankenhaus Brustzentrum; 🇩🇪 Kassel, Germany

Manial Specialized Hospital; Oncology; 🇪🇬 Cairo, Egypt

Fakultní Nemocnice V Motole; Radioterapeuticko-Onkologicke Oddeleni; 🇨🇿 Praha 5, Czechia

Centre Hartmann; 🇫🇷 Levallois Perret, France

Ch Bretagne Sud Site Scorff; Oncologie Medicale; 🇫🇷 Lorient, France

Hopital Clinique Claude Bernard; Oncologie Medicale; 🇫🇷 Metz, France

Universitätsklinikum Essen; Zentrum Für Frauenheilkunde; 🇩🇪 Essen, Germany

Internist; Praxis Für Haemotologie & Onkologie; 🇩🇪 Bad Soden, Germany

Vivantes Klinikum Am Urban; Zentrum für Brusterkrankungen; 🇩🇪 Berlin, Germany

Praxis Dres. Schilling & Till; 🇩🇪 Berlin, Germany

Polyclinique Du Bois; Centre Bourgogne; 🇫🇷 Lille, France

Centre Azureen De Cancerologie; Cons externes; 🇫🇷 Mougins, France

Centre Antoine Lacassagne; B3 Medecine Conventionnelle; 🇫🇷 Nice, France

Klinikum St. Georg GmbH; Franziskus-Hospital Harderberg; Klinik für Gynaekologie und Geburtshilfe; 🇩🇪 Georgsmarienhütte, Germany

Krankenhaus St. Elisabeth und St. Barbara, Klinik für Frauenheilkunde und Geburtshilfe; 🇩🇪 Halle, Germany

Klinikum Augsburg; Frauenklinik; 🇩🇪 Augsburg, Germany

Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH; Klinik für Senologie / Brustzentrum; 🇩🇪 Essen, Germany

Klinikum Leverkusen; Med. Klinik III / Onkologie; 🇩🇪 Leverkusen, Germany

Universitätsklinikum Freiburg; Frauenklinik; 🇩🇪 Freiburg, Germany

Katholische Hospitalvereinigung Ostwestfalen gGmbH; 🇩🇪 Bielefeld, Germany

Kliniken der Stadt Köln gGmbH Krankenhaus Holweide; Brustzentrum; 🇩🇪 Köln, Germany

Hopital Albert Michallon; Oncologie; 🇫🇷 La Tronche, France

Ch Du Mans; Medecine Hematologie Oncologie; 🇫🇷 Le Mans, France

Clinique Victor Hugo; 🇫🇷 LeMans, France

Hopital Cochin; Unite Fonctionnelle D Oncologie; 🇫🇷 Paris, France

Onkologische Schwerpunktpraxis Lübeck; 🇩🇪 Lübeck, Germany

Nationales Centrum für Tumorerkrankungen (NCT) ; Gyn. Onk. Frauenklinik; Uniklinikum Heidelberg; 🇩🇪 Heidelberg, Germany

Gynaekologisch-Onkologische Schwerpunktpraxis Prof. Dr. med. Lueck, Dr. Schrader und Dr. Noeding; 🇩🇪 Hannover, Germany

Laiko General Hospital; 1St Pathological Clinic; 🇬🇷 Athens, Greece

Gemeinschaftspraxis Fr. Dr. med. Balser & Hr. Dr. med. Weidenbach; 🇩🇪 Marburg, Germany

Dres. Andreas Köhler und Roswitha Fuchs; 🇩🇪 Langen, Germany

Alexandras General Hospital of Athens; Oncology Department; 🇬🇷 Athens, Greece

Agioi Anargyroi Cancer Hospital; 2Nd Oncology Dept.; 🇬🇷 Kifisia, Greece

Azienda Ospedaliera A. Cardarelli; 🇮🇹 Napoli, Campania, Italy

Mühlenkreiskliniken; Johannes Wesling Klinikum Minden; Klinik für Frauenheilkunde und Geburtshilfe; 🇩🇪 Minden, Germany

Oncologianova GmbH; 🇩🇪 Recklinghausen, Germany

Anticancer Hospital Ag Savas; 1St Dept of Internal Medicine; 🇬🇷 Athens, Greece

Papageorgiou General Hospital; Medical Oncology; 🇬🇷 Thessaloniki, Greece

Asst Papa Giovanni XXIII; Oncologia Medica; 🇮🇹 Bergamo, Lombardia, Italy

IRRCCS San Matteo; Dip Oncoematologico ; Divisione Oncologia; 🇮🇹 Pavia, Lombardia, Italy

Leopoldina Krankenhaus der Stadt Schweinfurt GmbH; 🇩🇪 Schweinfurt, Germany

Lahn-Dill Kliniken GmbH Klinikum Wetzlar Gynäkologie/Geburtshilfe; 🇩🇪 Wetzlar, Germany

Grupo Angeles; 🇬🇹 Guatemala City, Guatemala

Katharinen-Hospital gGmbH; 🇩🇪 Unna, Germany

HELIOS Klinikum Schwerin; Frauenklinik; 🇩🇪 Schwerin, Germany

Ausl Frosinone - Ospedale Umberto I; Divisione Di Oncologia; 🇮🇹 Frosinone, Lazio, Italy

Markusovszky Hospital; 🇭🇺 Szombathely, Hungary

ASKLEPIOS KREISKRANKENHÄUSER WEIßENFELS-HOHENMÖLSEN GMBH; 🇩🇪 Weißenfels, Germany

IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica; 🇮🇹 Meldola, Emilia-Romagna, Italy

Ospedale Civile; Oncologia Medica; 🇮🇹 Camposampiero, Veneto, Italy

Hospital Pulau Pinang; Jabatan Radioterapi & Onkologi; 🇲🇾 Georgetown, Malaysia

Ospedale Civile SS Annunziata; oncologia medica; 🇮🇹 Sassari, Sardegna, Italy

Klaipeda University Hospital; 🇱🇹 Klaipeda, Lithuania

Sarawak General Hospital; Department of Radiotherapy, Oncology and Palliative care; 🇲🇾 Sarawak, Malaysia

Clinica de Especialidades Medicas; 🇵🇪 Lima, Peru

Azlenda Ospendaliero-Universitaria Pisana; C.O. Oncologia 2; 🇮🇹 Pisa, Toscana, Italy

Yonsei University Severance Hospital; Medical Oncology; 🇰🇷 Seoul, Korea, Republic of

Helse Stavanger HF, Stavanger Universitetssjukehus; Klinikk for Blod og kreftsykdommer; 🇳🇴 Stavanger, Norway

Shifa International Hospital; Department of Oncology; 🇵🇰 Islamabad, Pakistan

Shaukat Khanum Memorial Cancer Hospital; Department of Oncology; 🇵🇰 Lahore, Pakistan

Instituto Nacional de Enfermedades Neoplasicas; 🇵🇪 Lima, Peru

Instituto Oncologico de Lima; 🇵🇪 LIma, Peru

Centro Medico Monte Carmelo; 🇵🇪 Arequipa, Peru

Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Klinika Onkologii; 🇵🇱 Otwock, Poland

Fakultna nemocnica Trencín; Onkologicke odd.; 🇸🇰 Trencin, Slovakia

East Avenue Medical Center; 🇵🇭 Quezon City, Philippines

Oddzial Chemioterapii Szpitala Klinicznego Nr 1 w Poznaniu; 🇵🇱 Poznan, Poland

S.C. Life Search S.R.L; Medical Oncology Clinic; 🇷🇴 Timisoara, Romania

King Faisal Specialist Hospital & Research Centre; 🇸🇦 Jeddah, Saudi Arabia

Clinical Center Kragujevac; 🇷🇸 Kragujevac, Serbia

Centro Clinico Champalimaud; Oncologia Medica; 🇵🇹 Lisboa, Portugal

Aga Khan University; Department of Oncology; 🇵🇰 Karachi, Pakistan

Hameed Latif Hospital; Department of Oncology; 🇵🇰 Lahore, Pakistan

Centro Hemato Oncologico Panama; 🇵🇦 Panama, Panama

Wielkopolskie Centrum Onkologi; 🇵🇱 Poznan, Poland

NZOZ Onko-Dent SP. P. G. L. Slomian, Poradnia Onkologiczna; 🇵🇱 Zory, Poland

Hospital de Sao Joao; Servico de Oncologia; 🇵🇹 Porto, Portugal

Institut of Oncology Al. Trestioreanu Bucharest; Oncology Department; 🇷🇴 Bucuresti, Romania

ONCOMED - Medical Centre; 🇷🇴 Timisoara, Romania

Hospital de Basurto; Servicio de Oncologia; 🇪🇸 Bilbao, Vizcaya, Spain

Wojewodzki Szpital Zespolony; 🇵🇱 Torun, Poland

Hospital da Luz; Departamento de Oncologia Medica; 🇵🇹 Lisboa, Portugal

Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia; 🇪🇸 Badalona, Barcelona, Spain

Westridge Medical Center; 🇿🇦 Durban, South Africa

Donald Gordon Medical Centre; 🇿🇦 Johannesburg, South Africa

State Inst. Of Healthcare Orenburg Regional Clinical Oncology Dis; 🇷🇺 Orenburg, Russian Federation

City Clinical Oncology Dispensary, SPb SBIH CCOD; 🇷🇺 Saint-Petersburg, Russian Federation

Clinical Hospital Center Bezanijska kosa; Clinic for Oncology; 🇷🇸 Belgrade, Serbia

Institute for Onc/Rad Serbia; 🇷🇸 Belgrade, Serbia

Vychodoslovensky onkologicky ustav; 🇸🇰 Košice, Slovakia

Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia; 🇪🇸 Barcelona, Spain

Corporacio Sanitaria Parc Tauli; Servicio de Oncologia; 🇪🇸 Sabadell, Barcelona, Spain

Complejo Asistencial Universitario De Burgos; Servicio de Oncologia; 🇪🇸 Burgos, Spain

University Medical Centre Maribor; Depart. of Gynecology & Breast Oncology; 🇸🇮 Maribor, Slovenia

Hospital Universitario Marques de Valdecilla; Servicio de Oncologia; 🇪🇸 Santander, Cantabria, Spain

IInstituto Oncologico de San Sebastian, Oncologikoa; Servicio de Oncologia; 🇪🇸 San Sebastian, Guipuzcoa, Spain

Hospital Quiron de Madrid; Servicio de Oncologia; 🇪🇸 Pozuelo de Alarcon, Madrid, Spain

Hospital General Univ. de Alicante; Servicio de Oncologia; 🇪🇸 Alicante, Spain

Hospital Clinico Universitario Lozano Blesa; Servicio de Oncologia; 🇪🇸 Zaragoza, Spain

Complejo Hospitalario Nuestra Señora de la Candelaria; Servicio de Oncologia; 🇪🇸 Santa Cruz de Tenerife, Tenerife, Spain

Gaziantep Univ. Med. Fac.; 🇹🇷 Gaziantep, Turkey

Hospital de Navarra; Servicio de Oncologia; 🇪🇸 Navarra, Spain

Wexham Park Hospital; Oncology; 🇬🇧 Berkshire, United Kingdom

Instituto Oncológico Luis Razetti; 🇻🇪 Caracas, Venezuela

Centro Integral de Oncología; 🇻🇪 Caracas, Venezuela

Royal Perth Hospital; Department of Medical Oncology; 🇦🇺 Perth, Western Australia, Australia

University "Mother Theresa" Hospital Center; Oncology Department; 🇦🇱 Tirana, Albania

MHAT Serdika; Department of medical oncology; 🇧🇬 Sofia, Bulgaria

University Hospital Limerick; 🇮🇪 Limerick City, Ireland

IFO - Istituto Regina Elena; Oncologia Medica; 🇮🇹 Roma, Lazio, Italy

Azienda Ospedaliera Sant'Andrea; 🇮🇹 Roma, Lazio, Italy

British Columbia Cancer Agency (Bcca) - Vancouver Cancer Centre; 🇨🇦 Vancouver, British Columbia, Canada

Josa Andras Korhaz; Dept of Oncoradiology; 🇭🇺 Nyíregyháza, Hungary

Mater Private Hospital; 🇮🇪 Dublin, Ireland

Beaumont Hospital; Cancer Clinical Trials Unit; 🇮🇪 Dublin, Ireland

Policlinico Umberto i di Roma; dip. Scienze Radiologiche, Oncologiche, Anatomopatologiche; 🇮🇹 Roma, Lazio, Italy

Peninsula and South Eastern Haematology and Oncology Group; 🇦🇺 Frankston, Victoria, Australia

University Hospital of Larissa; Oncology; 🇬🇷 Λαρισα, Greece

Waterford Regional Hospital; Department Of Medical Oncology; 🇮🇪 Waterford, Ireland

Ospedale Oncologico Regionale; U.O. Oncologia Medica Ed Ematologia; 🇮🇹 Rionero in Vulture, Basilicata, Italy

Centro Estatal de Cancerología; 🇲🇽 Chihuahua, Mexico

Centro Estatal de Cancerologia de Nayarit; 🇲🇽 Tepic, Mexico

Catharina Ziekenhuis; Dept of Internal Medicin; 🇳🇱 Eindhoven, Netherlands

Atrium Medisch Centrum Parkstad, Heerlen; 🇳🇱 Heerlen, Netherlands

St. Antonius Ziekenhuis Nieuwegein; 🇳🇱 Nieuwegein, Netherlands

MRUKMED Lekarz Beata Madej-Mruk i Partner Spolka Partnerska Oddzial nr 1 w Rzeszowie; 🇵🇱 Rzeszow, Poland

Oncology Institute of Vojvodina; 🇷🇸 Sremska Kamenica, Serbia

Russian Oncology Research Center n.a. N.N. Blokhin Dpt of Clinical Pharmacology and Chemotherapy; 🇷🇺 Moscow, Russian Federation

Clinical Hospital 1 Craiova; Medical Oncology; 🇷🇴 Craiova, Romania

Hospital of Lithuanian University of Health. Sciences Kaunas Clinics; 🇱🇹 Kaunas, Lithuania

Centro Estatal de Oncología de Campeche; 🇲🇽 Campeche, Mexico

National Cancer Centre; Medical Oncology; 🇸🇬 Singapore, Singapore

Zuyderland ziekenhuis locatie Geleen; 🇳🇱 Sittard-Geleen, Netherlands

Clinica Internacional, Sede San Borja; Unidad de Investigacion de Clínica Internacional; 🇵🇪 Lima, Peru

SC Oncolab SRL; 🇷🇴 Craiova, Romania

Regional Oncology Hospital; 🇷🇺 Irkutsk, Russian Federation

Hospital Universitario Son Espases; 🇪🇸 Palma De Mallorca, Islas Baleares, Spain

Vlietland Ziekenhuis, Locatie Schiedam; Interne Geneeskunde; 🇳🇱 Schiedam, Netherlands

Oslo universitetssykehus HF, Ullevål, Kreftsenteret; 🇳🇴 Oslo, Norway

Philippine General Hospital; Section Of Medical Oncology; 🇵🇭 Manila, Philippines

Cluj Clinical County Hospital; Oncology Dept; 🇷🇴 Cluj-Napoca, Romania

Fakultna nemocnica s poliklinikou J.A. Reimana Presov; 🇸🇰 Presov, Slovakia

CHUV; Departement d'Oncologie; 🇨🇭 Lausanne, Switzerland

Department of Surgery, King Chulalongkorn Memorial Hospital; 🇹🇭 Bangkok, Thailand

Hospital de Gran Canaria Dr. Negrin; Servicio de Oncologia; 🇪🇸 Las Palmas de Gran Canaria, LAS Palmas, Spain

Poradnia Onkologiczna oraz Oddzial Kliniczny Onkologii SPZOZ Szpital Uniwersytecki; 🇵🇱 Kraków, Poland

IPO do Porto; Servico de Oncologia Medica; 🇵🇹 Porto, Portugal

Emergency University Bucharest Hospital; Oncology Department; 🇷🇴 Bucharest, Romania

Prof. Dr. I. Chiricuta Institute of Oncology; 🇷🇴 Cluj Napoca, Romania

City Oncological Hospital; 🇷🇺 Izhevsk, Russian Federation

King Abdul Aziz Medical City, King Fahd National Guard; Oncology; 🇸🇦 Riyadh, Saudi Arabia

Clinical Centre Nis, Clinic for Oncology; 🇷🇸 Nis, Serbia

Ikazia Ziekenhuis; 🇳🇱 Rotterdam, Netherlands

Zaans Medisch Centrum; 🇳🇱 Zaandam, Netherlands

Bashkirian Republican Clinical Oncology Dispensary; 🇷🇺 UFA, Russian Federation

Kantonsspital Frauenfeld, Frauenklinik Thurgau; 🇨🇭 Frauenfeld, Switzerland

Maharaj Nakorn Chiang Mai Hospital; Department of Surgery/Head Neck and Breast Unit; Clinical Trial; 🇹🇭 Chiang Mai, Thailand

Tawam Hospital; 🇦🇪 Al Ain, United Arab Emirates

Hospital Universitario Materno Infantil de Gran Canaria; Servicio de Oncologia; 🇪🇸 Las Palmas de Gran Canaria, LAS Palmas, Spain

Ospedale San Giovanni; Oncologia; 🇨🇭 Bellinzona, Switzerland

Spital Thun; Medizinische Klinik; 🇨🇭 Thun, Switzerland

Kyiv City Clinical Oncological Center; Chemotherapy Department; 🇺🇦 Kiev, Ukraine

Hospital General de Elda; Servicio de Oncologia; 🇪🇸 Elda, Alicante, Spain

Pramongkutklao Hospital; Medicine - Medical Oncology Unit; 🇹🇭 Bangkok, Thailand

Hospital Do Meixoeiro; Servicio de Oncologia; 🇪🇸 Vigo, Pontevedra, Spain

Istituto Nazionale Tumori Irccs Fondazione g. PASCALE;U.O.C. Oncologia Medica Senologica; 🇮🇹 Napoli, Campania, Italy

Ospedale Regionale Di Parma; Divisione Di Oncologia Medica; 🇮🇹 Parma, Emilia-Romagna, Italy

Azienda USL di Ravenna; Unità Operativa di Oncologia Medica; 🇮🇹 Ravenna, Emilia-Romagna, Italy

Ospedale Garibaldi Nesima; Biomedicina Clinica e Molecolare; 🇮🇹 Catania, Sicilia, Italy

Istanbul Uni of Medicine Faculty; Oncology Dept; 🇹🇷 Istanbul, Turkey

Hôpital Saint Joseph; Oncologie Medicale; 🇫🇷 Marseille, France

Clinique Sainte Marie; Chimiotherapie; 🇫🇷 Chalon Sur Saone, France

Clinique Sainte Marguerite; Oncologie Medicale; 🇫🇷 Hyeres, France

HOPITAL TENON; Cancerologie Medicale; 🇫🇷 Paris, France

Ctre Consultations La Sauvegarde; 🇫🇷 Lyon, France

Hopital Claude Huriez; Medecine Interne Oncologie; 🇫🇷 Lille, France

CHRA;Hematologie; 🇫🇷 Metz Tessy, France

Ch Francois Mitterrand; Medecine Oncologie; 🇫🇷 Pau, France

Ch Lyon Sud; Onco Secteur Jules Courmont; 🇫🇷 Pierre Benite, France

Chp Saint Gregoire; Cancerologie Radiotherapie; 🇫🇷 Saint Gregoire, France

Ico Rene Gauducheau; Oncologie; 🇫🇷 Saint Herblain, France

Clinique de L'Union; Oncologie; 🇫🇷 Saint Jean, France

Ch De Saint Quentin; Medecine B10; 🇫🇷 Saint Quentin, France

Centre Paul Strauss; Oncologie Medicale; 🇫🇷 Strasbourg, France

Hopitaux Du Leman Site Thonon; Maternite Gynecologie; 🇫🇷 Thonon Les Bains, France

Clinique Radio Des Dentellieres; Chimiotherapie Radiotherapie; 🇫🇷 Valenciennes, France

Centre-Alexis Vautrin; 🇫🇷 Vandoeuvre-les-Nancy, France

Clinique Pasteur; Pneumologie; 🇫🇷 Toulouse, France

Praxis Dr.med. Katja Ziegler-Löhr; 🇩🇪 Köln, Germany

Klinikum Ludwigsburg; Klinik für Frauenheilkunde und Geburtshilfe; 🇩🇪 Ludwigsburg, Germany

Klinikum Memmingen; Abt.Gynäkologie; 🇩🇪 Memmingen, Germany

Praxis Dr. Prechtl & Dr. Kowolik; Frauenklinik; 🇩🇪 München, Germany

Sana Klinikum Offenbach GmbH; Klinik für Gynäkologie & Geburtshilfe; 🇩🇪 Offenbach, Germany

Agaplesion Diakonieklinikum Rotenburg; 🇩🇪 Rotenburg/Wümme, Germany

Johanniter-Krankenhaus Genthin-Stendal; Klinik Für Frauenheilkunde & Geburtshilfe; 🇩🇪 Stendal, Germany

Kreiskrankenhaus Torgau; Abt.Gynäkologie und Geburtshilfe; 🇩🇪 Torgau, Germany

medius KLINIK OSTFILDERN-RUIT; Brustzentrum; 🇩🇪 Ostfildern, Germany

GRN-Klinik Weinheim; Abt.Gynäkologie und Geburtshilfe; 🇩🇪 Weinheim, Germany

Gesellschaft für Medizinische Studien Würselen; 🇩🇪 Wuerselen, Germany

HOSPITAL DE MADRID NORTE SANCHINARRO- CENTRO INTEGRAL ONCOLOGICO CLARA CAMPAL; Servicio de Oncologia; 🇪🇸 Madrid, Spain

Complejo Hospitalario de Toledo- H. Virgen de la Salud; Servicio de Oncologia; 🇪🇸 Toledo, Spain

Franciscus Ziekenhuis; 🇳🇱 Roosendaal, Netherlands

Sørlandet Sykehus Kristiansand; 🇳🇴 Kristiansand, Norway

CPMC; Service d'Oncologie Médicale; 🇩🇿 Algiers, Algeria

Fundación CENIT para la Investigación en Neurociencias; 🇦🇷 Buenos Aires, Argentina

Chris O'Brien Lifehouse; 🇦🇺 Camperdown, New South Wales, Australia

Hospital Britanico; Oncologia; 🇦🇷 Buenos Aires, Argentina

Instituto De Investigaciones Clinicas Zarate; 🇦🇷 Zarate, Argentina

Princess Alexandra Hospital; Division of Cancer Services; 🇦🇺 Woolloongabba, Queensland, Australia

Prince of Wales Hospital; Oncology; 🇦🇺 Randwick, New South Wales, Australia

Queen Elizabeth Hospital; Medical Oncology; 🇦🇺 Woodville South, South Australia, Australia

Western Hospital; 🇦🇺 Footscray, Victoria, Australia

Cabrini Medical Centre; Oncology; 🇦🇺 Malvern, Victoria, Australia

University Clinical Center of the Republic of Srpska; 🇧🇦 Banja Luka, Bosnia and Herzegovina

Clinic of Oncology, University Clinical Center Sarajevo; 🇧🇦 Sarajevo, Bosnia and Herzegovina

Hospital Sao Rafael - HSR; 🇧🇷 Salvador, BA, Brazil

Centro de Oncologia da Bahia - CENOB; 🇧🇷 Salvador, BA, Brazil

Hospital Amaral Carvalho; 🇧🇷 Jau, SP, Brazil

Instituto do Cancer do Estado de Sao Paulo - ICESP; 🇧🇷 Sao Paulo, SP, Brazil

Hospital Perola Byington; 🇧🇷 Sao Paulo, SP, Brazil

Complex Oncology Center - Plovdiv First Internal Chemotherapy Department; 🇧🇬 Plovdiv, Bulgaria

Cross Cancer Institute ; Dept of Medical Oncology; 🇨🇦 Edmonton, Alberta, Canada

SHATOD - Sofia; 🇧🇬 Sofia, Bulgaria

The Moncton Hospital; 🇨🇦 Moncton, New Brunswick, Canada

Lakeridge Health Oshawa; Oncology; 🇨🇦 Oshawa, Ontario, Canada

Windsor Regional Cancer Centre; 🇨🇦 Windsor, Ontario, Canada

CSSS champlain - Charles-Le Moyne; 🇨🇦 Greenfield Park, Quebec, Canada

Clinical Hospital Centre Zagreb; 🇭🇷 Zagreb, Croatia

Mcgill University - Royal Victoria Hospital; Oncology; 🇨🇦 Montreal, Quebec, Canada

Centro Oncológico Antofagasta; 🇨🇱 Antofagasta, Chile

Instituto Nacional del Cancer; 🇨🇱 Santiago, Chile

Sociedad de Investigaciones Medicas Ltda (SIM); 🇨🇱 Temuco, Chile

Hospital Carlos Van Buren, Servicio de Oncologia; 🇨🇱 Valparaiso, Chile

Clinica del Country; 🇨🇴 Bogota, Colombia

St. Michael'S Hospital; 🇨🇦 Toronto, Ontario, Canada

Hospital Solca Quito; Oncologia; 🇪🇨 Quito, Ecuador

Fondation Clement Drevon; Oncology; 🇫🇷 Dijon, France

Ch De Brive La Gaillarde; Radiotherapie Oncologie; 🇫🇷 Brive La Gaillarde, France

Hopital Prive Drome Ardeche; Chir 2A 2B; 🇫🇷 Guilherand Granges, France

CHD Les Oudairies; 🇫🇷 La Roche Sur Yon, France

CH Bretagne Sud Site Bodelio; Oncologie Radiotherapie; 🇫🇷 Lorient, France

Clinique Clementville; Hopital De Jour; 🇫🇷 Montpellier, France

CMCO De La Cote D Opale; Auberge De Jour; 🇫🇷 St Martin Boulogne, France

Hopital Hotel Dieu; Oncologie Medicale; 🇫🇷 Paris, France

Institut de Cancerologie de La Loire; Pneumologie; 🇫🇷 Saint-priest-en-jarez, France

Institut Claudius Regaud; Departement Oncologie Medicale; 🇫🇷 Toulouse, France

DONAU ISAR Klinikum Deggendorf; Frauenklinik; 🇩🇪 Deggendorf, Germany

Universitätsklinikum Hamburg-Eppendorf; Zentrum für operative Medizin Klinik für Gynäkologie; 🇩🇪 Hamburg, Germany

Medizinische Hochschule Hannover, Klinik für Frauenheilkunde und Geburtshilfe; 🇩🇪 Hannover, Germany

St. Elisabeth Krankenhaus Köln GmbH; Gynäkologie und Geburtshilfe; 🇩🇪 Koeln, Germany

Universitätsklinikum Jena; Klinik und Poliklinik für Frauenheilkunde und Fortpflanzungsmedizin; 🇩🇪 Jena, Germany

Klinikum Kulmbach; Frauenklinik; 🇩🇪 Kulmbach, Germany

Universitätsmedizin Mainz; Klinik u. Poliklinik f. Geburtshilfe u. Frauenheilkunde; 🇩🇪 Mainz, Germany

Klinikum Meiningen Klinik f.Gynäkologie und Geburtshilfe; 🇩🇪 Meiningen, Germany

Gemeinschaftspraxis Prof. Dr.med. Christoph Salat und Dr.med. Oliver J. Stötzer; 🇩🇪 München, Germany

Praxis Dr.med. Steffi Busch; 🇩🇪 Mühlhausen, Germany

Ruppiner Kliniken, Klinik fuer Gynaekologie und Geburtshilfe; 🇩🇪 Neuruppin, Germany

Caritas Klinik St. Theresia -Frauenklinik Brustzentrum; 🇩🇪 Saarbruecken, Germany

Klinikum Nord Frauenklinik; 🇩🇪 Nürnberg, Germany

Euromedical General Clinic of Thessaloniki; Oncology Department; 🇬🇷 Thessaloniki, Greece

Periph. University General Hospital of Heraklion Crete; Oncology Department; 🇬🇷 Heraklion, Greece

Uni Hospital of Alexandroupoli; Dept. of Oncology - Duth; 🇬🇷 Αλεξανδρουπολη, Greece

Centro Oncológico Sixtino / Centro Oncológico SA; 🇬🇹 Guatemala, Guatemala

Szent Margit Hospital; Dept. of Oncology; 🇭🇺 Budapest, Hungary

Orszagos Onkologiai Intezet; 🇭🇺 Budapest, Hungary

Szent Imre Hospital; Dept. of Oncology; 🇭🇺 Budapest, Hungary

Pécsi Tudományegyetem; Klinikai Központ Onkoterápiás Intézet; 🇭🇺 Pécs, Hungary

Debreceni Egyetem Klinikai Kozpont ; Department of Oncology; 🇭🇺 Debrecen, Hungary

Semmelweis Egyetem Aok; Iii.Sz. Belgyogyaszati Klinika; 🇭🇺 Budapest, Hungary

Hasan Sadikin Hospital; Internal Medicine; 🇮🇩 Bandung, Indonesia

Dharmais National Cancer Center; 🇮🇩 Jakarta, Indonesia

CiptoMangunkusumo Hospital; Internal Medicine; 🇮🇩 Central Jakarta, Indonesia

Mater Misericordiae Uni Hospital; Oncology; 🇮🇪 Dublin, Ireland

Soetomo Hospital; Surgery; 🇮🇩 East Java, Indonesia

Sardjito Hospital; Instalasi Kanker Tulip; 🇮🇩 Jogjakarta, Indonesia

Sligo General Hospital; Oncology; 🇮🇪 Sligo, Ireland

Università degli Studi Federico II; Clinica di Oncologia Medica; 🇮🇹 Napoli, Campania, Italy

Az. Osp. Ospedale Civile; U.O. Di Oncologia Medica Ed Ematologia; 🇮🇹 Piacenza, Emilia-Romagna, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori; S. C. Oncologia Medica 2; 🇮🇹 Milano, Lombardia, Italy

ASST DI CREMONA; Unità di Patologia Mammaria Senologia e Breast Unit; 🇮🇹 Cremona, Lombardia, Italy

ASST DI MONZA; Oncologia Medica; 🇮🇹 Monza, Lombardia, Italy

Irccs Ist. Tumori Giovanni Paolo Ii; Dipartimento Oncologia Medica; 🇮🇹 Bari, Puglia, Italy

IRCCS Istituto Clinico Humanitas; Oncologia; 🇮🇹 Rozzano, Lombardia, Italy

A.O. Città della Salute e della Scienza - Presidio Molinette; divisione oncologia medica; 🇮🇹 Torino, Piemonte, Italy

Ospedale Vito Fazzi; Div. Oncoematologia; 🇮🇹 Lecce, Puglia, Italy

IRCCS Ospedale Casa Sollievo Della Sofferenza; Oncologia; 🇮🇹 San Giovanni Rotondo, Puglia, Italy

Ospedale Oncologico A.Businco; Div. Oncologia Medica II; 🇮🇹 Cagliari, Sardegna, Italy

Azienda Ospedaliero-Universitaria Careggi;S.C. Oncologia Medica 1; 🇮🇹 Firenze, Toscana, Italy

Azienda usl 5 Di Pisa-Ospedale Di Pontedera;U.O. Oncologia; 🇮🇹 Pontedera, Toscana, Italy

Arcispedale S.Anna; Oncologia Medica; 🇮🇹 Cona (Ferrara), Veneto, Italy

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of

Korea University Guro Hospital; 🇰🇷 Seoul, Korea, Republic of

Asan Medical Center.; 🇰🇷 Seoul, Korea, Republic of

University Malaya Medical Centre; Clinical Oncology Unit,; 🇲🇾 Kuala Lumpur, Malaysia

Hospital Wanita dan Kanak-Kanak Sabah; 🇲🇾 Sabah, Malaysia

Instituto Nacional de Cancerologia; Oncology; 🇲🇽 Distrito Federal, Mexico

Oaxaca Site Management Organization; 🇲🇽 Oaxaca, Mexico

Consultorio de Medicina Especializada; Dentro de Condominio San Francisco; 🇲🇽 Mexico City, Mexico

Cancerologia de Queretaro; Oncologia; 🇲🇽 Queretaro, Queretaro, Mexico

Institut National D'oncologie Sidi Med Benabdellah; 🇲🇦 Rabat, Morocco

Onze Lieve Vrouwe Gasthuis; 🇳🇱 AC Amsterdam, Netherlands

Gelre Ziekenhuis Apeldoorn, Lokatie Lukas; Afdeling Interne Geneeskunde; 🇳🇱 Apeldoorn, Netherlands

Jeroen Bosch Ziekenhuis; 🇳🇱 'S Hertogenbosch, Netherlands

Ziekenhuis Gelderse Vallei; Inwendige Geneeskunde; 🇳🇱 EDE, Netherlands

Rijnstate Ziekenhuis; Inwendige Geneeskunde; 🇳🇱 Arnhem, Netherlands

Albert Schweitzer Ziekenhuis - loc Dordrecht; 🇳🇱 Dordrecht, Netherlands

Martini Ziekenhuis; Dept of Internal Medicine; 🇳🇱 Groningen, Netherlands

Maxima Medisch Centrum; Inwendige Geneeskunde; 🇳🇱 Eindhoven, Netherlands

Spaarne Ziekenhuis; Inwendige Geneeskunde; 🇳🇱 Hoofddorp, Netherlands

Ziekenhuis VieCurie Vitaal; 🇳🇱 Venlo, Netherlands

Maasstad ziekenhuis; Afdeling oncologie hematologie; 🇳🇱 Rotterdam, Netherlands

Diakonessenhuis Utrecht: ziekenhuisapotheek; 🇳🇱 Utrecht, Netherlands

Tauranga Hospital, Clinical Trials Unit; BOP Clinical School; 🇳🇿 Tauranga, New Zealand

Policlinica Sfanta Maria - Oncology; Medical Oncology; 🇷🇴 Baia Mare, Romania

National Cancer Institute - Comenius University; Dept. Clinical Oncology; 🇸🇰 Bratislava, Slovakia

Mammacentrum sv. Agáty; 🇸🇰 Banská Bystrica, Slovakia

Steve Biko Academic Hospital; Oncology; 🇿🇦 Pretoria, South Africa

Hospital de Cabueñes; Servicio de Oncologia; 🇪🇸 Gijon, Asturias, Spain

Hospital Universitario de Canarias;servicio de Oncologia; 🇪🇸 La Laguna, Tenerife, Spain

Hospital Lluis Alcanys; Servicio de Oncologia; 🇪🇸 Xativa, Valencia, Spain

Complejo Hospitalario Universitario de Albacete; Servicio de Oncologia; 🇪🇸 Albacete, Spain

Hospital del Mar; Servicio de Oncologia; 🇪🇸 Barcelona, Spain

Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia; 🇪🇸 Jaen, Spain

Hospital Duran i Reynals; Oncologia; 🇪🇸 Barcelona, Spain

Hospital San Pedro De Alcantara; Servicio de Oncologia; 🇪🇸 Caceres, Spain

Complejo Asistencial Universitario de Leon; Servicio de Oncologia; 🇪🇸 Leon, Spain

Hospital Universitari Arnau de Vilanova de Lleida; Servicio de Oncologia; 🇪🇸 Lerida, Spain

Hospital Ramon y Cajal; Servicio de Oncologia; 🇪🇸 Madrid, Spain

Hospital Universitario Virgen de Arrixaca; Servicio de Oncologia; 🇪🇸 Murcia, Spain

Hospital Arnau de Vilanova (Valencia) Servicio de Oncologia; 🇪🇸 Valencia, Spain

Skånes University Hospital, Skånes Department of Onclology; 🇸🇪 Lund, Sweden

Skaraborgs sjukhus Skoevde, Dept of surgery; 🇸🇪 Skoevde, Sweden

Hirslanden Medical Center, Tumorzentrum; 🇨🇭 Aarau, Switzerland

Kantonsspital Baden; Frauenklinik; 🇨🇭 Baden, Switzerland

Inselspital Bern; Universitätsklinik für medizinische Onkologie; 🇨🇭 Bern, Switzerland

Kantonsspital Winterthur; Medizinische Onkologie; 🇨🇭 Winterthur, Switzerland

National Taiwan Uni Hospital; General Surgery; 🇨🇳 Taipei, Taiwan

Ipswich Hospital; 🇬🇧 Ipswich, United Kingdom

China Medical University Hospital; Surgery; 🇨🇳 Taichung, Taiwan

National Cheng Kung Uni Hospital; Surgery; 🇨🇳 Tainan, Taiwan

Stadtspital Triemli; Frauenklinik; 🇨🇭 Zürich, Switzerland

Tri-Service General Hospital, Division of General Surgery; 🇨🇳 Taipei, Taiwan

Rajvithi Hospital; 🇹🇭 Bangkok, Thailand

Ramathibodi Hospital; Medicine/Oncology; 🇹🇭 Bangkok, Thailand

Oncology Unit, Faculty of Medicine, Vajira Hospital; Department of Medicine; 🇹🇭 Dusit, Thailand

Ankara Uni School of Medicine; Medical Oncology; 🇹🇷 Ankara, Turkey

Akdeniz University Medical Faculty; Medical Oncology Department; 🇹🇷 Antalya, Turkey

Dicle University Faculty of Medicine; 🇹🇷 Diyarbakir, Turkey

Marmara Uni Faculty of Medicine; Medical Oncology; 🇹🇷 Istanbul, Turkey

Kocaeli University Faculty of Medicine; Medical oncology; 🇹🇷 Izmit, Turkey

Mersin University Medical Faculty; 🇹🇷 Mersin, Turkey

19 Mayis University Medical Faculty; Medical Oncology Department; 🇹🇷 Samsun, Turkey

Hacettepe Uni Medical Faculty Hospital; Oncology Dept; 🇹🇷 Sihhiye/Ankara, Turkey

State Oncology Regional Treatment-Diagnostic Center; Chemotherapy Department; 🇺🇦 Lviv, Ukraine

Nevill Hall Hospital; 🇬🇧 Abergavenny, United Kingdom

University Hospital Birmingham Queen Elizabeth Hospital; 🇬🇧 Birmingham, United Kingdom

Bedford Hospital; Oncology; 🇬🇧 Bedford, United Kingdom

Broomfield Hospital; Oncology; 🇬🇧 Chelmsford, United Kingdom

Glan Clwyd Distr Gen Hospital;Nth Wales Cancer Treatment Ctr; 🇬🇧 Denbighshire, United Kingdom

Royal Bournemouth Hospital; Oncology; 🇬🇧 Bournemouth, United Kingdom

Heartlands Hospital; Department Of Medicine; 🇬🇧 Birmingham, United Kingdom

Kent & Canterbury Hospital; 🇬🇧 Canterbury, United Kingdom

North Devon District Hospital; 🇬🇧 Devon, United Kingdom

Royal Derby Hospital; 🇬🇧 Derby, United Kingdom

Russells Hall Hospital; Oncology; 🇬🇧 Dudley, United Kingdom

University Hospital of North Durham; 🇬🇧 Durham, United Kingdom

Beatson West of Scotland Cancer Centre; 🇬🇧 Glasgow, United Kingdom

Inverclyde Hospital; 🇬🇧 Greenock, United Kingdom

Royal Surrey County Hospital; 🇬🇧 Guildford, United Kingdom

Diana Princess of Wales Hosp.; 🇬🇧 Grimsby, United Kingdom

Huddersfield Royal Infirmary; 🇬🇧 Huddersfield, United Kingdom

Princess Alexandra Hospital; Oncology Department; 🇬🇧 Harlow, United Kingdom

Forth Valley Royal Hospital ; Oncology Department; 🇬🇧 Larbert, United Kingdom

Crosshouse Hospital; Dept of Oncology; 🇬🇧 Kilmarnock, United Kingdom

Leicester Royal Infirmary; 🇬🇧 Leicester, United Kingdom

St John's Hospital; 🇬🇧 Livingston, United Kingdom

Guys and St Thomas NHS Foundation Trust, Guys Hospital; 🇬🇧 London, United Kingdom

Queen Elizabeth Hospital; 🇬🇧 London, United Kingdom

St George's Hospital; 🇬🇧 London, United Kingdom

Macclesfield District General Hospital; 🇬🇧 Macclesfield, United Kingdom

Freeman Hospital; Northern Centre For Cancer Care; 🇬🇧 New Castle Upon Tyne, United Kingdom

Royal Shrewsbury Hospital; Pharmacy Department; 🇬🇧 Shrewsbury, United Kingdom

Christie Hospital; Breast Cancer Research Office; 🇬🇧 Manchester, United Kingdom

North Tyneside General Hospital; 🇬🇧 North Shields, United Kingdom

Northampton General Hospital NHS Trust; 🇬🇧 Northampton, United Kingdom

Poole General Hospital; 🇬🇧 Poole, United Kingdom

Derriford Hospital; Plymouth Oncology Centre; 🇬🇧 Plymouth, United Kingdom

Royal Preston Hospital; 🇬🇧 Preston, United Kingdom

Queen Alexandra Hospital, Portsmouth; 🇬🇧 Portsmouth, United Kingdom

Queens Hospital; R&D; 🇬🇧 Romford, United Kingdom

Scarborough General Hospital; 🇬🇧 Scarborough, United Kingdom

Southampton General Hospital; 🇬🇧 Southampton, United Kingdom

Royal Gwent Hospital; 🇬🇧 Newport, United Kingdom

Sunderland Royal Hospital; 🇬🇧 Sunderland, United Kingdom

Singleton Hospital; Pharmacy Department; 🇬🇧 Swansea, United Kingdom

Great Western Hospital, Swindon Cancer Research Unit; Osprey Unit Level 3; 🇬🇧 Swindon, United Kingdom

Royal Cornwall Hospital; 🇬🇧 Truro, United Kingdom

Royal Hampshire County Hospital; Winchester & Andover Breast Unit; 🇬🇧 Winchester, United Kingdom

The Clatterbridge Cancer Ctr For Oncolgy; 🇬🇧 Wirral, United Kingdom

Grupo Oncológico Cooperativo Uruguayo; Hospital de Clínicas - Dpto. de Oncología; 🇺🇾 Montevideo, Uruguay

The Royal Wolverhampton Hospitals NHS Trust; 🇬🇧 Wolverhampton, United Kingdom

Airedale General Hospital; Oncology; 🇬🇧 York, United Kingdom

York District Hospital; 🇬🇧 York, United Kingdom

Hospital Militar; Oncologia; 🇺🇾 Montevideo, Uruguay

Hospital Pereira Rossell; Oncology Department; 🇺🇾 Montevideo, Uruguay

Centro Médico Docente La Trinidad; Unidad de Protocolos Clínicos; 🇻🇪 Caracas, Venezuela

K hospital; 🇻🇳 Hanoi, Vietnam

City Clinical Oncology Hospital; 🇷🇺 Moscow, Russian Federation

Hospital Moinhos de Vento; 🇧🇷 Porto Alegre, RS, Brazil

Kooperatives Mammazentrum Hamburg Krankenhaus Jerusalem; 🇩🇪 Hamburg, Germany

Universitätsklinik Tübingen; Frauenklinik; 🇩🇪 Tübingen, Germany

Hospital Universitario Clínico San Carlos; Servicio de Oncologia; 🇪🇸 Madrid, Spain

National Cancer Center; 🇰🇷 Goyang-si, Korea, Republic of

St George Hospital; Cancer Care Centre; 🇦🇺 Kogarah, New South Wales, Australia

Universitätsklinikum Schleswig-Holstein / Campus Lübeck; Klinik für Frauenheilkunde und Geburtshilfe; 🇩🇪 Lübeck, Germany

Universitätsklinikum Münster; Klinik für Frauenheilkunde und Geburtshilfe; 🇩🇪 Münster, Germany

Ospedale Belcolle Di Viterbo; Oncologia; 🇮🇹 Viterbo, Lazio, Italy

Queen Elizabeth Hospital; Clinical Oncology; 🇭🇰 Hong Kong, Hong Kong

Prince of Wales Hosp; Dept. Of Clinical Onc; 🇭🇰 Shatin, Hong Kong