ISRCTN17632637已完成不适用
Effects of olanzapine standard oral tablets and orally disintegrating tablets on gut hormones, glucose metabolism and pituitary hormones
eiden University Medical Centre (LUMC) (The Netherlands)0 个研究点目标入组 12 人开始时间: 2007年4月11日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 12
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Male
入选标准
- •1. Healthy men without a positive family history of schizophrenia
- •2. Age between 20 and 40 years
- •3. Fasting plasma glucose less than 6 mmol/L
- •4. Body Mass Index (BMI) between 20 and 26 kg/m^2
排除标准
- •1. Fasting plasma glucose greater than 6 mmol/L
- •2. BMI greater than 26 kg/m^2
- •3. Psychiatric disorder and/or use of antipsychotic or antidepressants drugs at present or in the past
- •4. Gastrointestinal operations in the past
- •5. Any significant chronic disease
- •6. Renal, hepatic or endocrine disease
- •7. Use of medication known to influence lipolysis and or glucose metabolism
- •8. Total cholesterol greater than 7 mmol/L and or triglycerides greater than 2 mmol/L
- •9. Recent weight changes or attempts to lose weight (greater than 3 kg weight gain or loss, within the last three months)
- •10. Difficulties to insert an intravenous catheter
- •11. Smoking (current)
- •12. Alcohol/drug abuse
- •13. Severe claustrophobia
- •14. Recent blood donation (within the last two months)
- •15. Recent participation in other research projects (within the last three months), participation in two or more projects in one year
- •16. Extensive sporting activities (more than ten hours of exercise per week)
研究者
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Effects of Olanzapine standard oral tablets and orally disintegrating tablets on gut hormones, glucose metabolism and pituitary hormones.engels: antipsychotic drugs, type 2 diabetes mellitus, insulin resistanceNederlands: antipsychoticum, diabetes mellitus type 2, insuline resistentieNL-OMON29380H. Pijl, Department Endocrinology and Metabolism, Leiden University Medical Center, C4-R, P.O. Box 9600, RC Leiden, The Netherlands.Telefon number: 31 71 5263082e-mail adres: h.pijl@lumc.nl12
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