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Clinical Trials/NCT07564973
NCT07564973CompletedNot Applicable

The Effect of Adiponectin-Leptin Ratio on Weight Loss in Patients Undergoing Sleeve Gastrectomy Due to Morbid Obesity

Sercan YUKSEL, MD1 site in 1 country78 target enrollmentStarted: January 1, 2025Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
78
Locations
1
Primary Endpoint
Change in body mass index at 8 months

Study Overview

Brief Summary

The study aims to find out if a specific blood test, measuring the balance between two hormones (adiponectin and leptin), can predict how much weight a person might lose after sleeve gastrectomy, a surgery for obesity. The investigators want to see if this hormone ratio can help identify who will benefit most from the surgery. If the investigators find that people with a low hormone ratio are less likely to lose weight after surgery, doctors can guide them toward other weight-loss options, like lifestyle changes or different treatments, instead of surgery. This way, patients can get the care that's best for them.

Detailed Description

The subject of the research is to investigate whether preoperative adiponectin-leptin ratios are predictive of weight loss in patients undergoing sleeve gastrectomy for morbid obesity. If the study finds the adiponectin-leptin ratio to be a significant predictor of weight loss, individuals with a low preoperative ratio, which are expected to lose less weight following surgery, can be redirected to more suitable treatment options other than sleeve gastrectomy. This will allow patients less likely to benefit from surgery to be guided toward conservative approaches.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to 75 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Patients aged 18 to 75
  • International Classification of Diseases (ICD) code E66 diagnosis (obesity)
  • Patients who have given consent for sleeve gastrectomy
  • Patients who are suitable for general anesthesia

Exclusion Criteria

  • Patients who did not give consent to be included in the study
  • Patients who are scheduled for surgery other than sleeve gastrectomy

Arms & Interventions

Sleeve Gastrectomy Patients

Patients who meet inclusion criteria for the study undergoing sleeve gastrectomy

Intervention: Laparoscopic Sleeve Gastrectomy (Procedure)

Outcomes

Primary Outcomes

Change in body mass index at 8 months

Time Frame: 8 months after surgery

Secondary Outcomes

  • Change in lipid profile at 8 months(8 months after surgery)

Investigators

Sponsor
Sercan YUKSEL, MD
Sponsor Class
Other Gov
Responsible Party
Sponsor Investigator
Principal Investigator

Sercan YUKSEL, MD

Associate Professor

Başakşehir Çam & Sakura City Hospital

Study Sites (1)

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