The Effect of Adiponectin-Leptin Ratio on Weight Loss in Patients Undergoing Sleeve Gastrectomy Due to Morbid Obesity
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 78
- Locations
- 1
- Primary Endpoint
- Change in body mass index at 8 months
Study Overview
Brief Summary
The study aims to find out if a specific blood test, measuring the balance between two hormones (adiponectin and leptin), can predict how much weight a person might lose after sleeve gastrectomy, a surgery for obesity. The investigators want to see if this hormone ratio can help identify who will benefit most from the surgery. If the investigators find that people with a low hormone ratio are less likely to lose weight after surgery, doctors can guide them toward other weight-loss options, like lifestyle changes or different treatments, instead of surgery. This way, patients can get the care that's best for them.
Detailed Description
The subject of the research is to investigate whether preoperative adiponectin-leptin ratios are predictive of weight loss in patients undergoing sleeve gastrectomy for morbid obesity. If the study finds the adiponectin-leptin ratio to be a significant predictor of weight loss, individuals with a low preoperative ratio, which are expected to lose less weight following surgery, can be redirected to more suitable treatment options other than sleeve gastrectomy. This will allow patients less likely to benefit from surgery to be guided toward conservative approaches.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients aged 18 to 75
- •International Classification of Diseases (ICD) code E66 diagnosis (obesity)
- •Patients who have given consent for sleeve gastrectomy
- •Patients who are suitable for general anesthesia
Exclusion Criteria
- •Patients who did not give consent to be included in the study
- •Patients who are scheduled for surgery other than sleeve gastrectomy
Arms & Interventions
Sleeve Gastrectomy Patients
Patients who meet inclusion criteria for the study undergoing sleeve gastrectomy
Intervention: Laparoscopic Sleeve Gastrectomy (Procedure)
Outcomes
Primary Outcomes
Change in body mass index at 8 months
Time Frame: 8 months after surgery
Secondary Outcomes
- Change in lipid profile at 8 months(8 months after surgery)
Investigators
Sercan YUKSEL, MD
Associate Professor
Başakşehir Çam & Sakura City Hospital