Automated Quantification of Radiologic Pulmonary Alteration During Acute Respiratory Failure: Application to the COVID-19 Pandemic : Prospective Multicenter Cohort Study

University Hospital, Strasbourg, France2 sites in 1 country500 target enrollmentJune 13, 2022

ConditionsSARS-CoV-2 Infections Respiratory Failure With Hypoxia

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: SARS-CoV-2 Infections
Sponsor: University Hospital, Strasbourg, France
Enrollment: 500
Locations: 2
Primary Endpoint: Correlation between altered pulmonary volume and ordinal severity scale
Status: Recruiting
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Automated quantification of the pulmonary volume impaired during acute respiratory failure could be helpful to assess patient severity during COVID-19 infection or perioperative medicine, for example.

This study aims at assessing the correlation between the amount of radiologic pulmonary alteration and the clinical severity in two clinical situation :

SARS-CoV-2 infections
Postoperative hypoxemic acute respiratory failure.

Registry

clinicaltrials.gov

Start Date

June 13, 2022

End Date

June 2025

Last Updated

3 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

University Hospital, Strasbourg, France

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Subject admitted to a care unit of the University Hospitals of Strasbourg or the University Hospital of Nancy and presenting a suspicion of SARS-CoV-2 infection or postoperative hypoxemic respiratory failure
•Able to understand the objectives and risks of the research and to give dated and signed informed consent.
•Subjects may also be included in emergency or immediate life-threatening situations.
•Subject with insurance covering

Exclusion Criteria

•Pregnant woman (pregnancy confirmed by a urine or blood test)
•Subject usually on home oxygen therapy
•Subject under court protection
•Subject under guardianship or curatorship

Outcomes

Primary Outcomes

Correlation between altered pulmonary volume and ordinal severity scale

Time Frame: 2 days after CT scan (Day 2)

This criterion will be expressed as a score between 1 (least severe) and 7 (most severe).

Secondary Outcomes

Mortality(90 days following CT scan (Day 90))
Initial length of hospitalization stay (in days)(90 days following CT scan (Day 90))
Correlation between altered pulmonary volume and ordinal severity scale(7 days after CT scan (Day 7))
Rate of admission to intensive care unit(28 days following CT scan (Day 28))