MRI in McArdle Disease (GSDV)

Completed

• Conditions: Glycogen Storage Disease Type V
• Interventions: Diagnostic Test: MRI

• Registration Number: NCT03844022
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

The aim of this study is to describe the degree of muscle wasting in patients with McArdle disease judged by MRI, quantitative magnetic resonance (DIXON) and T1 weighted images, and muscle strength, collected across multiple European sites and compared to healthy controls.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-03-01
• Study First Submitted: 2018-12-12
• Study First Submitted QC: 2019-02-15
• Study First Posted: 2019-02-18
• Primary Completion: 2021-02-01
• Study Completion: 2021-02-01
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-10
• Last Update Posted: 2023-02-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 87

Inclusion Criteria

• GSDV or healthy controls

Exclusion Criteria

• MRI contradictions

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healty controls	MRI	Age and gender matched
McArdle disease	MRI	Glycogen storage disease

Primary Outcome Measures

Name	Time	Method
DIXON MRI	1 time	Whole body quantitative muscle fat fraction analyses (DIXON)

Secondary Outcome Measures

Name	Time	Method
Back pain questionnaire	1 time	Back pain questionnaire
Muscle strength	1 time	MRC scale
T1 MRI	1 time	Whole body qualitative muscle fat fraction analyses (T1)

Trial Locations

Locations (1)

Copenhagen Neuromuscular Center, Rigshospitalet; 🇩🇰 Copenhagen, Denmark