T-BIRD: Tissue Biomechanics and Inflammation in the Rheumatic Diseases

Not Applicable

Recruiting

• Conditions: Rheumatoid Arthritis; Psoriatic Arthritis; Benign Joint Hypermobility; Cardiovascular Disease; Musculoskeletal - Other muscular and skeletal disorders; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system; Inflammatory and Immune System - Rheumatoid arthritis

• Registration Number: ACTRN12617000170325
• Lead Sponsor: Dr Stephen Oakley

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-02-01
• Last Update Posted: 21 September 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 375

Inclusion Criteria

Main Study
Case Groups
1.ACPA-positive Rheumatoid Arthritis (RA);
2.People at risk of developing ACPA-positive RA;
a.First Degree Relatives of people with ACPA-Positive RA;
b.People with a positive ACPA blood test who do not have RA;
3.Psoriatic Arthritis (PsA)
4.Cutaneous Psoriasis without psoriatic arthritis
Control Groups
1.Healthy Controls Unrelated to people with RA ;
2.Benign Joint Hypermobility (BJH)

Syringe Test Sub-Study
1. Any medical condition requiring corticosteroid therapy that does not affect the skin (e.g. giant cell arteritis, asthma, interstitial lung disease or systemic vasculitis).

Exclusion Criteria

Main Study

Syringe Test Sub-Study
Conditions affecting the skin such as psoriasis, Systemic Lupus Erythematosus, scleroderma or high alcohol intake;

Case or Control groups for the study – RA, PsA, psoriasis, Joint Hypermobility;
Prior corticosteroid exposure.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
A specially designed device constructed from Meccano will be used to measure angular displacement of 5th finger metacarpophalangeal joint in response to torque applied to extend the finger. The right hand is strapped into the device positioned such that the 5th finger MCP can be extended by rotation of a lever arm attached to a pulley through which forces can be applied to generate a range of torques to extend the finger. [Baseline (cross-sectional study)];Endothelial Function (Peripheral Arterial Tonometry) - EndoPAT Device[Baseline (Cross-sectional Study)];Skin Elasticity (Syringe Test) - Volume Displacement in Response to Negative Pressure (suction force) applied to dominant forearm.<br>[Baseline (cross-sectional study)]