A Case Control Study of the Prevalence of Pulmonary Hypertension in Patients With Myeloproliferative Diseases, and Correlation Between Patients Epidemiologic and Clinical Status and the Development of Pulmonary Hypertension.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- pulmonary hypertension
研究概览
简要总结
Pulmonary hypertension (PH) is defined as a group of diseases characterised by an elevated mean pulmonary artery pressure (Ppa) ≥25 mmHg at rest. Recently, chronic myeloproliferative diseases (CMPD) associated with pulmonary hypertension were included in the group 5 category, corresponding to PH for which the aetiology is unclear and/or multifactorial. CMPD include chronic myelogenous leukaemia, chronic neutrophilic leukaemia and chronic eosinophilic leukaemia (which primarily express a myeloid phenotype and polycythaemia vera), idiopathic myelofibrosis, and essential thrombocytosis in which erythroid or megakaryocytic hyperplasia predominates.
The purpose of this research:
- Assess Prevalence of PH in patients with CMPD in Northern Israel
- Describe the demographics and clinical course in patients with CMPD who are diagnosed with PH.
详细描述
study will include the following:
- sex
- age
- BMI
- ethnicity
- age diagnosed with Myeloproliferative disease
- clinical manifestations of the myeloproliferative disease
- JAK2 mutation
- known hematological complications
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •consenting patients diagnosed with a myeloproliferative disease
排除标准
- •Refusal to have an echocardiogram or answer the St. George respiratory questionnaire
结局指标
主要结局
pulmonary hypertension
时间窗: 1 year
all patients with myeloproliferative diseases in the study will be evaluated by an echocardiogram. Pulmonary hypertension will be considered when the average pulmonary arterial pressure is equal or above 25 mmHg.
次要结局
- St George Respiratory Questionnaire(1 year)
研究者
Shoshan Perek
Dr Shoshan Perek
Carmel Medical Center