A Case Control Study of the Prevalence of Pulmonary Hypertension in Patients With Myeloproliferative Diseases, and Correlation Between Patients Epidemiologic and Clinical Status and the Development of Pulmonary Hypertension.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myeloproliferative Disease
- Sponsor
- Carmel Medical Center
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- pulmonary hypertension
- Last Updated
- 10 years ago
Overview
Brief Summary
Pulmonary hypertension (PH) is defined as a group of diseases characterised by an elevated mean pulmonary artery pressure (Ppa) ≥25 mmHg at rest. Recently, chronic myeloproliferative diseases (CMPD) associated with pulmonary hypertension were included in the group 5 category, corresponding to PH for which the aetiology is unclear and/or multifactorial. CMPD include chronic myelogenous leukaemia, chronic neutrophilic leukaemia and chronic eosinophilic leukaemia (which primarily express a myeloid phenotype and polycythaemia vera), idiopathic myelofibrosis, and essential thrombocytosis in which erythroid or megakaryocytic hyperplasia predominates.
The purpose of this research:
- Assess Prevalence of PH in patients with CMPD in Northern Israel
- Describe the demographics and clinical course in patients with CMPD who are diagnosed with PH.
Detailed Description
study will include the following: * sex * age * BMI * ethnicity * age diagnosed with Myeloproliferative disease * clinical manifestations of the myeloproliferative disease * JAK2 mutation * known hematological complications
Investigators
Shoshan Perek
Dr Shoshan Perek
Carmel Medical Center
Eligibility Criteria
Inclusion Criteria
- •consenting patients diagnosed with a myeloproliferative disease
Exclusion Criteria
- •Refusal to have an echocardiogram or answer the St. George respiratory questionnaire
Outcomes
Primary Outcomes
pulmonary hypertension
Time Frame: 1 year
all patients with myeloproliferative diseases in the study will be evaluated by an echocardiogram. Pulmonary hypertension will be considered when the average pulmonary arterial pressure is equal or above 25 mmHg.
Secondary Outcomes
- St George Respiratory Questionnaire(1 year)