Improving Working Memory in Older Adults by Restoring Large-Scale Cortical Interactions
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 964
- 试验地点
- 2
- 主要终点
- Memory performance success (active stimulation condition)
研究概览
简要总结
The research program will evaluate the theoretical claim that age-related memory and cognitive decline in humans result from the inefficient orchestration of rhythmic activity within large-scale cortical networks. The results will contribute to the basic science groundwork for developing future non-pharmacological interventions aimed at boosting memory and cognition in aging and clinical populations.
详细描述
The investigators hypothesize that aged-related memory and cognitive impairments emerge from large-scale functional dysconnectivity and by stimulating the brain noninvasively with extremely weak levels of electrical current, it may be possible to re-synchronize connectivity and stabilize or improve memory and cognitive function, measured behaviorally. The experiments of this project are proposed as between-subjects, sham-controlled, and double-blind in design, and use noninvasive electroencephalographic (EEG) measurements of rhythmic brain activity. The experimental intervention involves the application of low-intensity, high-definition, transcranial electrical current stimulation while subjects perform a variety of computer-based tasks that probe memory and cognitive function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For Experiment 1, 18-30 years
- •For Experiment 2, 60-80 years
- •Normal or corrected-to-normal vision
- •Has color vision.
排除标准
- •Metal implants in the head
- •Implanted electronic devices
- •A history of neurological problems or head injury
- •Skin sensitivity
- •Claustrophobia
- •Dementia [Mini Mental State Examination (MMSE) score of 23 or lower; Montreal Cognitive Assessment score of <26)
- •Depression [Beck Depression Inventory II score of 14 or higher; Geriatric Depression Scale score of 10 or higher]
- •Taking any psychoactive medication
研究组 & 干预措施
active stimulation
干预措施: High definition transcranial electrical current stimulation (Device)
sham stimulation
干预措施: High definition transcranial electrical current stimulation (Device)
结局指标
主要结局
Memory performance success (active stimulation condition)
时间窗: During active intervention
The accuracy of task performance (in percentage correct unit) in the delayed-match-to-sample working memory paradigm
Memory performance speed (sham stimulation condition)
时间窗: During sham intervention
The reaction time of task performance (in millisecond units) in the delayed-match-to-sample working memory paradigm
Memory performance success (sham stimulation condition)
时间窗: During sham intervention
The accuracy of task performance (in percentage correct units) in the delayed-match-to-sample working memory paradigm
Memory performance speed (active stimulation condition)
时间窗: During active intervention
The reaction time of task performance (in millisecond units) in the delayed-match-to-sample working memory paradigm
次要结局
未报告次要终点
研究者
Robert Reinhart
Assistant Professor
Boston University Charles River Campus