Working Memory Training and Neural Plasticity in Mild Cognitive Impairment
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Mild Cognitive Impairment
- Sponsor
- University of Michigan
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Changes in brain activation within the WM network
- Status
- Terminated
- Last Updated
- 6 months ago
Overview
Brief Summary
This study will evaluate the efficacy of working memory training in older adults with amnestic mild cognitive impairment (MCI).
Detailed Description
Working memory (WM) is the ability to hold information actively in mind and is fundamental for higher-order cognition. This pilot study aims to (1) evaluate the efficacy of WM training in older adults with MCI and (2) understand if and how it works. The study will use behavioral and brain imaging assessments to see whether WM training changes how participants learn and remember information. Functional magnetic resonance imaging (fMRI) and functional near infrared spectroscopy (fNIRS) methods will be used. The study will also use cognitive tests and questionnaires to determine whether participants' cognitive abilities change with training. The study will enroll participants with a diagnosis of MCI as well as cognitively intact older adults (healthy controls, HC).
Investigators
Alexandru Iordan
Principal Investigator
University of Michigan
Eligibility Criteria
Inclusion Criteria
- •MCI Diagnosis
- •Right-handedness
- •MRI-eligibility for MRI participants
Exclusion Criteria
- •History of other contributing neurological or medical conditions known to affect cognitive functioning
- •Significant mental illness
- •Sensory impairments that limit ability to participate
- •History of alcohol or drug abuse/dependence
Outcomes
Primary Outcomes
Changes in brain activation within the WM network
Time Frame: 2 weeks
Univariate analyses via fMRI and fNIRS, respectively, using units of brain activation (i.e., contrast estimates)
Gains in WM training task performance
Time Frame: 2 weeks
Analyses of WM performance for each training session indexed as the mean set-size achieved during each training session for each participant
Secondary Outcomes
- Changes in criterion (fMRI) WM task performance(2 weeks)
- Changes in functional connectivity within and between canonical brain networks(2 weeks)