Working Memory Training in Adults With Substance Abuse and Executive Function Deficits.

Phase 2

• Conditions: Executive Dysfunction; Reading Disabilities; Depression; Anxiety; Substance Abuse; Antisocial Personality

• Registration Number: NCT02068261
• Lead Sponsor: Örebro Läns Landsting

Brief Summary

The purpose of this study is to evaluate the effects of a computerized working memory training program on substance abuse, psychosocial functioning, cognitive performance and psychiatric problems in adults with substance abuse and attention problems.

Detailed Description

The primary aim of this study is to examine the effects of 5 weeks of computerized working memory training on substance abuse. Secondary aims are to explore whether effects are mediated by changes in executive functions and/or moderated by personality. Also, effects on measures of psychosocial functioning, depression, anxiety and attention will be explored. Follow-up assessment will be conducted at 6 months post training.

Study Timeline

• Study Start: 2014-01
• Study First Submitted: 2014-02-19
• Study First Submitted QC: 2014-02-20
• Study First Posted: 2014-02-21
• Status Verified: 2015-10
• Last Update Submitted: 2015-10-22
• Last Update Posted: 2015-10-23
• Primary Completion: 2016-12
• Study Completion: 2016-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Treatment seeking adults with substance abuse and executive function deficits.

Exclusion Criteria

• Acute intoxication or abstinence symptoms of any substance.
• Psychosis.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change from baseline in substance abuse measured with Substance abuse scales in Adult Self Report (ASR; ASEBA).	Baseline and at 25 weeks

Secondary Outcome Measures

Name	Time	Method
Change from baseline in Adult Self Report (ASR; ASEBA) Internalizing index.	Baseline and at 25 weeks
Change from baseline in focused attention measured with performance on Conners Continuous Performance Test-II (CCPT-II).	Baseline and at 25 weeks
Change from baseline in Adult Self Report (ASR; ASEBA) Externalizing index.	Baseline and at 25 weeks
Change from baseline in verbal working memory measured with performance on Digit span.	Baseline and at 25 weeks
Change from baseline in Adult Self Report (ASR; ASEBA) Attention problems scale.	Baseline and at 25 weeks
Change from baseline in Adult Self Report (ASR; ASEBA) Adaptive functioning scales.	Baseline and at 25 weeks
Change from baseline in Executive functioning measured with Behavior Rating Inventory of Executive Function-Adult (BRIEF-A).	Baseline and at 25 weeks
Change from baseline in visual working memory measured with performance on Span board.	Baseline and at 25 weeks
Change from baseline in vigilance measured with performance on Conners Continuous Performance Test-II (CCPT-II).	Baseline and at 25 weeks
Change from baseline in reading speed measured with performance on Reading speed in Diagnostic Reading and Writing Test (DLS; Swedish version).	Baseline and at 25 weeks

Trial Locations

Locations (1)

Psychiatric Research Centre; 🇸🇪 Örebro, Sweden