CT Perfusion Changes in GI Cancer During Adenosine Vasodilation Test

Completed

• Conditions: Esophageal Cancer; Gastric Cancer

• Registration Number: NCT02074124
• Lead Sponsor: University of Copenhagen

Brief Summary

The aim of this study was to investigate changes in abdominal tissue perfusion during adenosine vasodilation. Our hypotheses were that CT perfusion measurements are altered by changes in the circulatory system mediated by adenosine, and a more differentiated assessment of the circulatory capacity of abdominal tumours could be achieved by sequential rest and adenosine vasodilation CT perfusion measurements.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-10
• Primary Completion: 2013-08
• Study Completion: 2013-12
• Status Verified: 2014-02
• Study First Submitted: 2014-02-20
• Study First Submitted QC: 2014-02-26
• Last Update Submitted: 2014-02-26
• Study First Posted: 2014-02-28
• Last Update Posted: 2014-02-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Tumour larger than 1.5 cm on diagnostic CT
• Normal serum creatinine
• Age above 18
• Informed written and oral consent.

Exclusion Criteria

• Contrast allergy or contrast induced nephropathy
• BMI > 40
• Asthma or Chronic Obstructive Lung Disease
• Heart failure (NYHA III+)
• Heart conduction disorder
• Atrial fibrillation
• 2nd/3rd Heart block
• Long QT syndrome
• Wolf Parkinson White Syndrome
• Moderate / severe aortic stenosis
• Haemodynamic contraindications for adenosine, systolic pressure below 90

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in arterial flow during adenosine vasodilation test (CT perfusion parameter)	0 min and 15 min

Secondary Outcome Measures

Name	Time	Method
Change in Blood pressure during adenosine vasodilation test	0 min and 15 min
Change in Heart rate during adenosine vasodilation test	0 min and 15 min
Change in Area under arterial input curve during adenosine vasodilation test	0 min and 15 min	Area Under Curve (AUC) is correlated to cardiac output
Change in Blood volume (CT perfusion parameter) during adenosine vasodilation test	0 min and 15 min
Change in Permeability (CT perfusion parameter) during adenosine vasodilation test.	0 min and 15 min

Trial Locations

Locations (1)

Rigshospitalet; 🇩🇰 Copenhagen, Denmark