Esophageal epithelial permeability changes in patients with allergic esophagitis.
Recruiting
- Conditions
- Eosinophilic esophagitis, pathophysiology, etiology, epithelial barrier integrity, permeability.Eosinofiele oesofagitis, pathofysiologie, etiologie, epitheliale barrierefunctie, permeabiliteit.
- Registration Number
- NL-OMON28827
- Lead Sponsor
- Academic Medical Center, Amsterdam, The Netherlands
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 16
Inclusion Criteria
Eosinophilic esophagitis group:
1. Previous diagnosis of EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per high power field (hpf) in mid-esophageal biopsies before the start of any therapy;
Exclusion Criteria
Eosinophilic esophagitis group:
1. Inability to stop topical corticosteroids;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Size of esophageal epithelial intercellular spaces in EoE patients and healthy controls;<br /><br>2. Permeability of esophageal mucosa to small molecules in EoE patients and healthy controls;<br /><br>3. Tissue impedance of esophageal epithelium (in vivo) in EoE patients and healthy controls;<br /><br>4. Numbers of esophageal intraepithelial mast cells and eosinophils in EoE patients and healthy controls.
- Secondary Outcome Measures
Name Time Method Reversibility of abovementioned (permeability) changes by proton pump inhibition in EoE patients.