Impact of esophageal barrier function on proton pump inhibitor-resistant non erosive reflux disease (PPI-resistant NERD): discovering of pathophysiology and establishment of new therapeutic strategy
Not Applicable
- Conditions
- Proton pump inhibitor-resistant non erosive reflux disease (PPI-resistant NERD)
- Registration Number
- JPRN-UMIN000028300
- Lead Sponsor
- Tohoku university graduate school of medicine dept. gastroenterology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
<Only healthy volunteer> 1. Acid suppression drugs such as histamine 2 antagonist or PPI, Nsaids, steroids or immune suppression drugs were not administered 1 month before measurement of esophageal barrier function. <patients and volunteers> 2. scheduled or history of abdominal surgical operation 3. Patients who prohibited to underwent endoscopy 4. pregnancy 5. severe diseases 6. psychogenic diseases 7. Patients whom we decided inappropriate to join in this study.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method comparison of difference in upper and lower esophageal epithelium of esophageal barrier function by mini ussing chamber system among patients of PPI-resistant NERD, functional heart burn and healthy volunteer.
- Secondary Outcome Measures
Name Time Method 1. comparison of esophageal barrier function between patients with heart burn (PPI-resistant NERD and FH) and healthy volunteer. 2. comparison of esophageal tight junctional protein in the bisopy specimen among PPI-resistant NERD, FH and healthy volunteer. 3. validation of esophageal histopathological difference amaong PPI-resistant NERD, FH and healthy volunteer. 4. elucidating relationship with intraesophageal luminal pH and esophageal epithelial barrier function between PPI-resistant NERD and FH. 5. comparison of difference in esophageal reflux contents and epithelial barrier function between PPI-resistant NERD and FH