Effects of chemotherapy on neurobehaviour of cancer patients:an observational study

Recruiting

Conditions: Patients diagnosed with cancer undergoing chemotherapy were enrolled

Brief Summary: Patients undergoing chemotherapy for various kinds of cancer were assessed for cognitive assessment at three cycles of chemotherapy using MMSE score. Discarded blood samples were collected after each cycle for inflammation assessment using ELISA. Its an observational study to find out the correlation between cognition and inflammation by chemotherapy

Recruitment & Eligibility

Inclusion Criteria

1.Patient must have histologically and cytologically confirmed cancer.
2.Patient receiving chemotherapy for the treatment of cancer.
3.Both males and female patients.
4.Patient capable of giving informed consent 5.Patient willing to participate in the study.

Exclusion Criteria

1.History of cognitive impairment and Alzheimerâ€™s disease.
2.History of head injury 3.Patients had evidence of uncontrolled clinical diseases, including diabetes, rheumatologic diseases, asthamatic diseases or other chronic inflammatory conditions.
4.Patient having brain cancer.
5.Patient having neuropsychiatric disorders.
6.On any psychotropic medications.
7.History of schizophrenia and other neurological and neurobehavioural diseases.
9.Using any concurrent medication like Donepezil, rivastigmine, galantamine, Memantine Tacrine cholinergic drugs.
10.Patient using anti inflammatory drugs.
11.Alcoholics.
12.Incompetent for interview.

Primary Outcome Measures

Name	Time	Method
Assesment of neurobehaviour in cancer patients by validated questionnaire	1 day before 1st, 2nd and 3rd and 4th cycle of chemotherapy

Secondary Outcome Measures

Name	Time	Method
assesment of socioeconomic status of patient using questionnire	NA

Locations (1): Rajiv Gandhi Cancer Institute & Research Centre
🇮🇳
South, DELHI, India
Rajiv Gandhi Cancer Institute & Research Centre
🇮🇳South, DELHI, India
Dr Dinesh Bhurani
Principal investigator
09971500861
bhurani@gmail.com