Assessment of the Effect of Non-surgical Periodontal Treatment on Endothelial Function- a Prospective Study

Recruiting

• Conditions: Endothelial Dysfunction; Periodontal Diseases
• Interventions: Diagnostic Test: Assessment of pulse wave amplitude (PWA); Diagnostic Test: Salivary Nitric Oxide

• Registration Number: NCT05691426
• Lead Sponsor: University of Sharjah

Brief Summary

An association between periodontitis and endothelial dysfunction has been reported, suggesting that periodontitis presents an inflammatory burden to the cardiovascular system, that might lead to AVD. The study aims aim to assess whether non-surgical periodontal therapy enhances endothelial function in periodontitis patients using a non-invasive diagnostic device to assess endothelial function through PWA and the assessment of levels of salivary Endothelin-1, in a population of people in the UAE.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-01
• Status Verified: 2023-01
• Study First Submitted: 2023-01-10
• Study First Submitted QC: 2023-01-10
• Study First Posted: 2023-01-20
• Last Update Submitted: 2023-01-21
• Last Update Posted: 2023-01-25
• Primary Completion: 2023-12
• Study Completion: 2024-06

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Group 1: periodontally healthy subjects.
• Group 2: patients with periodontitis stage III or IV and grades A,B or C.

Exclusion Criteria

• Medical conditions: Diabetes,pregnancy,obesity,renal disease,patients with cardiovascular diseases including hypertension,recent myocardial infarction or unstable angina (within 3 months),congestive heart failure,valvular heart disease
• Heavy smokers(>10 cigarettes per day),
• Regular administration of drugs resulting in gingival hyperplasia,root planning in the past 6 months
• Regular administration of drugs resulting in gingival hyperplasia (such as cyclosporine and phenytoin)
• Recent antibiotic use (in the past 3 months)
• Non-surgical periodontal therapy in the past 6 monthsp

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Test	Salivary Nitric Oxide	Periodontitis patients
Control	Salivary Nitric Oxide	Periodontally healthy patients
Test	Assessment of pulse wave amplitude (PWA)	Periodontitis patients
Control	Assessment of pulse wave amplitude (PWA)	Periodontally healthy patients

Primary Outcome Measures

Name	Time	Method
pulse wave amplitude	2 months

Trial Locations

Locations (1)

University Dental Hospital Sharjah; 🇦🇪 Sharjah, United Arab Emirates