NCT05691426招募中不适用
Assessment of the Effect of Non-surgical Periodontal Treatment on Endothelial Function- a Prospective Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- pulse wave amplitude
研究概览
简要总结
An association between periodontitis and endothelial dysfunction has been reported, suggesting that periodontitis presents an inflammatory burden to the cardiovascular system, that might lead to AVD. The study aims aim to assess whether non-surgical periodontal therapy enhances endothelial function in periodontitis patients using a non-invasive diagnostic device to assess endothelial function through PWA and the assessment of levels of salivary Endothelin-1, in a population of people in the UAE.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Group 1: periodontally healthy subjects.
- •Group 2: patients with periodontitis stage III or IV and grades A,B or C.
排除标准
- •Medical conditions: Diabetes,pregnancy,obesity,renal disease,patients with cardiovascular diseases including hypertension,recent myocardial infarction or unstable angina (within 3 months),congestive heart failure,valvular heart disease
- •Heavy smokers(>10 cigarettes per day),
- •Regular administration of drugs resulting in gingival hyperplasia,root planning in the past 6 months
- •Regular administration of drugs resulting in gingival hyperplasia (such as cyclosporine and phenytoin)
- •Recent antibiotic use (in the past 3 months)
- •Non-surgical periodontal therapy in the past 6 monthsp
结局指标
主要结局
pulse wave amplitude
时间窗: 2 months
次要结局
未报告次要终点
研究者
Zahi BADRAN
Professor
University of Sharjah
研究点 (1)
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