Effect of enoxaparin (a low molecular weight heparin) given in a single or split dose, on stroke occurrence after unruptured brain aneurysm treatment utilising coils or stents

Phase 2

Recruiting

• Conditions: Intracranial Aneurysm; Intracranial Lesions; Stroke - Ischaemic; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system; Neurological - Other neurological disorders

• Registration Number: ACTRN12620001128987
• Lead Sponsor: Professor Alan Coulthard

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-10-30
• Last Update Posted: 29 November 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 124

Inclusion Criteria

Patients admitted for elective endovascular treatment of intracranial aneurysm are eligible for inclusion.

Participants should understand the project and provide voluntary consent

Eligible patients will be admitted to the study if at the end of the endovascular procedure the operator determines that a period of post procedural anticoagulation is clinically indicated. The three most common reasons for this are:

1) Placement of an indwelling endovascular device, such as a stent
2) Presence of procedural platelet aggregation
3) Perceived increased risk of thromboembolic events due to
(3a) large area of coil exposure at aneurysm neck
(3b) loop protrusion into parent artery

Exclusion Criteria

- Under 18 years of age (i.e. paediatric population)
- Patients presenting with acute subarachnoid haemorrhage
- Patients with significantly impaired renal function (eGFR < 30)
- Patients not suitable for 3T MR imaging (e.g. pacemakers)
- Pregnant women
- Patients deemed not to require anti-coagulation post-procedure

Study & Design

• Study Type: Interventional
• Study Design: Not specified