Ageing BIOmarker Study in Singaporeans (ABIOS)
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 378
- 试验地点
- 1
- 主要终点
- blood DNA methylation
研究概览
简要总结
The Ageing BIOmarker Study in Singaporeans (ABIOS) aims to understand the biological aging processes and how they affect health among people in Singapore. As people grow older, their risk of developing chronic diseases increases. This study aims to better understand the biological changes that come with age, particularly in three major ethnic groups: Chinese, Malay, and Indian adults over 21 years old. By examining a range of health indicators such as DNA methylation, inflammation, metabolism, cardiovascular health, physical function, and physical activity (i.e., molecular, physiological, and digital biomarkers of ageing), the study seeks to identify how ethnicity, lifestyle, and socioeconomic factors influence ageing. This unique study focuses on an all-Asian population, aiming to enhance our understanding of healthy aging across different ethnic groups.
详细描述
Biological ageing is the primary driver of age-associated chronic diseases in older adults. Asian populations have been underrepresented in studies developing biological age predictors and understanding age-related diseases. Thus, the Ageing BIOmarker Study in Singaporeans (ABIOS) aims to characterise the biomarkers of ageing in Singaporeans, exploring associations between molecular, physiological, and digital biomarkers of ageing.
This is a single-centre, cross-sectional study that recruits healthy community-dwelling adults (≥ 21 years) from three different ethnic groups (Chinese, Malay, and Indian). Molecular biomarkers of ageing include a multi-omics approach, such as DNA methylation and metabolic and inflammatory parameters in blood, saliva, and stool. Physiological biomarkers of ageing include bone density, body composition, skin autofluorescence, arterial stiffness, physical performance (e.g., muscle strength and flexibility), cognition, and nutritional status. Digital biomarkers of ageing include three-dimensional facial morphology and objective physical activity. Additional factors such as habitual physical activity, dietary patterns, and medical history are also examined. The associations between the molecular, physiological, and digital phenotypes will be explored.
By examining diverse age-related biomarkers, clinical indicators, and lifestyle factors, ABIOS will offer unique insights into the ageing process within these ethnic groups to develop health policies and interventions for promoting healthy ageing in an all-Asian population.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •≥21 years of age
- •Chinese, Malay, or Indian and has lived in Singapore for at least 5 consecutive years
- •Apparently healthy and non-smokers
- •Having only 1 condition (if ≥45 and <65 years) or any condition (if ≥65 years), and all conditions were medication-controlled (if any):
- •Hypertension
- •Hyperlipidemia
- •Hyperglycemia
- •Osteopenia/osteoporosis
- •Osteoarthritis
- •Type 2 diabetes
排除标准
- •Body mass index (BMI) ≥30 kg/m^2
- •Pre-existing or history of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke, peripheral vascular disease)
- •Any metal implants (excluding dental implants) in the body
- •Pre-existing or history of cancer or chronic obstructive pulmonary disease (COPD)
- •Pregnant women or planning pregnancy in the next 6-12 months
研究组 & 干预措施
Singaporean adults
Adults greater than 21 years of age living in Singapore of Chinese, Malay, or Indian ethnicity.
结局指标
主要结局
blood DNA methylation
时间窗: Baseline
DNA methylation ageing clock, years
次要结局
- Handgrip strength(Baseline)
- 8-repetition maximal strength(Baseline)
- Complete red blood cell (RBC) count(Baseline)
- Triglycerides(Baseline)
- Total white blood cell (WBC) count(Baseline)
- Fasting blood glucose(Baseline)
- Carotid-femoral Pulse Wave Velocity(Baseline)
- Objective physical activity(Baseline)
- Facial age(Baseline)
- Total cholesterol(Baseline)
- HDL cholesterol(Baseline)
- HbA1c(Baseline)
- LDL cholesterol(Baseline)
- Total protein(Baseline)
- Total bilirubin(Baseline)
- Alkaline phosphatase (ALP)(Baseline)
- Insulin(Baseline)
- Skin advanced glycation endproducts(Baseline)
研究者
Andrea Maier
Oon Chiew Seng Professor in Medicine, Healthy Ageing and Dementia Research
National University of Singapore