Biological Age in Health Promotion - Novel Health Technology
- Conditions
- AgingHealthy
- Registration Number
- NCT03680768
- Lead Sponsor
- University of Copenhagen
- Brief Summary
The purpose of this cross-sectional study is to collect relevant molecular markers of aging and measures of physiological function. Together these biomarkers are used to develope a new Biological Age model, useful in health promotion interventions in the public health sector .
- Detailed Description
Study design: 100 participants representing the healthy danish working adult population. This study seek to include both men and women equally distributed in the range of 18-65 of age.
Data collection: After recruitment, participants need to attend once to the laboratory, overnight fasted and without having exercised for the previous 24 hours.
All analyse are done in investigators lab (Xlab) at the department of Biomedical Sciences, Copenhagen University. When analyzes are done, the results are used in algorithm developement in cooperation with Technical university Denmark.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- Males and females interested in their personal health status
- Healthy males and females
- Pregnancy
- Previous or current cardiovascular disease
- Use of medication that affects our measurements such as betablockers,statins or medication that affects the metabolism.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Biological Age Day 1 A composite score of ones biological state (in years)
- Secondary Outcome Measures
Name Time Method Muscle mass Day 0 muscle mass(g) is assessed by dual energy x-ray absorptiometry (DXA) and bioimpedance
Blood glucose Day 0 HbA1c and fasting glucose (mmol/L) measured from blood sample
Blood profile Day 0 Haematocrit and Haemoglobin (mmol/L) measured in a blood sample
Aging biomarker Day 0 Chemokines Eotaxin (CCL11) analysed from blood samples
Youth biomarker Day 0 Growth Differential Factor (GDF-11) analysed from blood samples
Central obesity Day 0 Waist to hip ratio is measured by dividing waist circumference with hip circumference in cm.
Lipid profile Day 0 HighDensityLipoprotein (mmol/L), LowDensityLipoprofile (mmol/L), TriGlycerides (mmol/L), FreeFattyAcids (mmol/L) and Glycerol (mmol/L) is measured in a blood sample.
Levels of glycated protein and lipids as a result of exposure of excess sugars Day 0 advanced glycation endproducts (AGE) measured in the skin
Blood Pressure Day 0 Systolic and Diastolic blood pressure (mmHg)
Weight Day 0 measured in kilograms
Height Day 0 measured in cm
Fat percentage Day 0 Fat%, is assessed by DXA and bioimpedance
Respirometry Day 0 forced vital capacity and forced expiratory volume at one second(L)
Hormones Day 0 Sex hormones: testosteron and estradiol (nmol/L) and InsulinGrowthFactor-1 (nmol/L) and Insulin (µU/ml) ais analysed from blood samples
Inflammatory profile Day 0 C-reactive protein mg/L, soluble urokinase plasminogen activating receptor ng/ml, InterLeukin 6,8 and 10 (pg/mL), tumor necrosis factor (pg/mL), Leptin and Adiponectin (ng/ml) is analysed from blood samples
Color passport photography Day 0 Profile picture taken to assess perceived age
Fitness Level Day 0 VO2max - maximal oxygen consumption (ml/min/kg)
Strength Day 0 Hand grip, isometric quadriceps and biceps strength (Nm)
Sit to Stand test Day 0 Rise and sit from a chair as many times as possible during 1 minute (number og rises)
Body composition Day 0 BMI (kg/m2) is calculated
Fat mass Day 0 fat mass(g) is assessed by DXA and bioimpedance
Trial Locations
- Locations (1)
University of Copenhagen, Department of Biomedical Sciences
🇩🇰Copenhagen, Denmark
University of Copenhagen, Department of Biomedical Sciences🇩🇰Copenhagen, Denmark