Biological Age Applied at Ubberup
- Conditions
- Healthy AgingLifestyle Risk Reduction
- Interventions
- Behavioral: Lifestyle intervention
- Registration Number
- NCT04279366
- Lead Sponsor
- University of Copenhagen
- Brief Summary
In a previous study the investigators have developed a novel biological age model. Assessing biological age is the assessment of the present health status and functional capacity/physiological reserve of that person in comparison with people of the same age and sex.
The aim of this study is to investigate the utility and validity of this novel biological age model designed for health promotion in real world conditions.
- Detailed Description
Study design: This is a longitudinal study, where biological age assessment is conducted in the first and final week of an 11-14 week lifestyle intervention course. These courses take place at a Danish folk high school (Ubberup), which is specialized in performing intensive lifestyle interventions targeting a 10% weight loss. The intention is to include 80 adult men and women.
Data collection: This will take place at the facilities at Ubberup folk high school, participants being overnight fasted and without having exercised for the previous 24 hours. All analysis will be performed in investigators lab (Xlab) at the Department of Biomedical Sciences, Copenhagen University. When all samples are analysed Biological age will be calculated for each particpant.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 83
- Participation in a long course at Ubberup folk high school (12-15 weeks)
- Age between 18-65 years
- Previous or current cardiovascular disease
- Pregnancy
- Conditions that prevents from performing a cycle and/or strength tests
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Winter course Lifestyle intervention The recruited particpants attending the winter course Fall course Lifestyle intervention The recruited particpants attending the winter course
- Primary Outcome Measures
Name Time Method Change in biological age week1 and week 14 a composite score predicting risk of lifestyle related diseases
- Secondary Outcome Measures
Name Time Method Change in cardiorespiratory capacity week 1 and week 14 VO2max maximal oxygen consumption (ml/min/kg
Change in strength week 1 and week 14 Hand grip, isometric quadriceps and biceps strength (Nm)
Change in Sit to Stand test week 1 and week 14 Rise and sit from a chair as many times as possible during 1 minute (number og rises)
Change in Central obesity week 1 and week 14 Waist to hip ratio is measured by dividing waist circumference with hip circumference in cm.
Change in body weight week 1 and week 14 measured in kilograms
Change in body composition week 1 and week 14 BMI (kg/m2) is calculated
Change in fat mass week 1 and week 14 fat mass(g) is assessed by bioimpedance
Change in Hormones Week 1 and week 14 Insulin
Change in fat percentage week 1 and week 14 Fat%, is assessed by bioimpedance
Change in muscle mass week 1 and week 14 muscle mass(g) is assessed by bioimpedance
Change in lipid profile week 1 and week 14 HighDensityLipoprotein (mmol/L), LowDensityLipoprofile (mmol/L), TriGlycerides (mmol/L), FreeFattyAcids (mmol/L) and Glycerol (mmol/L) is measured in a blood sample.
Change in Respirometry week 1 and week 14 forced vital capacity and forced expiratory volume at one second(L)
Change in Inflammatory profile week 1 and week 14 C-reactive protein mg/L, soluble urokinase plasminogen activating receptor ng/ml, InterLeukin 6 and 8 (pg/mL), tumor necrosis factor (pg/mL), Leptin and Adiponectin (ng/ml) is analysed from blood samples
Change in Blood glucose week 1 and week 14 HbA1c and fasting glucose (mmol/L) measured from blood sample
Change in Blood Pressure week 1 and week 14 Systolic and Diastolic blood pressure (mmHg)
Change in Advanced glycation endproducts week 1 and week 14 Levels of glycated protein and lipids as a result of exposure of excess sugars advanced glycation endproducts (AGE) measured in the skin
Trial Locations
- Locations (2)
Ubberup High School
🇩🇰Kalundborg, Danmark, Denmark
Xlab, Faculty of Health and Medical Sciences, University of Copenhagen
🇩🇰Copenhagen, Denmark