Influence of the obstetric epidural analgesia on maternal, uteroplacental and fetoplacental hemodynamics in nomotensive parturients

• Conditions: O80; Single spontaneous delivery

• Registration Number: DRKS00020934
• Lead Sponsor: Klinik für Anästhesiologie und operative Intensivmedizin, Katholisches Klinikum Bochum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2017-09-21
• Study Start: 2020-03-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 64

Inclusion Criteria

Parturient with a single pregnancy after the 37th week of gestation
Planned vaginal delivery with a cervical dilation of at least 2 cm
cephalic presentation
Normal cardiotocogram
EDA group: EDA requested by the parturient
ASA physical status 2

Exclusion Criteria

parturients under 18 years of age
refusal to participate in this study
multiple pregnancy
- anamnestic hypotensive episodes,
- hypertensive or metabolic disorders of pregnancy
- intrauterine growth restriction (IUGR)
- cephalopelvic disproportion
- coagulopathy, thrombocytopaenia, or other contraindications for EDA.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pulsatility index (PI) of the umbilical artery 30 min after first epidural drug administration compared to PI before the injection

Secondary Outcome Measures

Name	Time	Method
pulsatility index (PI) of the umbilical artery 60 and 90 minutes after the initial epidural bolus dose<br>PIs of the fetal middle cerebral artery (MCA) and the uterine arteries at 30, 60 and 90 minutes after initial epidural bolus dose<br>maternal systolic blood pressure<br>Neonatal outcome data: APGAR scores at 5 minutes, umblical arterial pH, birth weight