Optic Nerve Perfusion Following Treatment with Latanoprost Versus Brimionidin Tartrate

Early Phase 1

Completed

• Conditions: Glaucoma
• Interventions: Drug: Latanoprost (Xalatan); Drug: Brimonidine 0.2 %

• Registration Number: NCT06730516
• Lead Sponsor: Zagazig University

Brief Summary

This study aimed to evaluate the effects of topical Latanoprost 0.005 % versus Brimionidin tartrate 0.2% on perfusion of optic nerve head This prospective interventional randomized study included 56 naive patients recently diagnosed with bilateral primary open angle glaucoma equally divided into two groups with 28 patients in each group

Detailed Description

This study aimed to evaluate the effects of topical Latanoprost 0.005 % versus Brimionidin tartrate 0.2% on perfusion of optic nerve head This prospective interventional randomized study included 56 naive patients recently diagnosed with bilateral POAG equally divided into two groups with 28 patients in each group. The whole VD was increased and also increased in all four nasal, temporal, superior, and inferior quadrants around optic disc from the initial vessel density before treatment (p\<0.001) in both groups significantly with superior improvement in group (1) compared to group (2) that was statistically significant

Study Timeline

• Status Verified: 2024-06
• Study Start: 2024-06-24
• Primary Completion: 2024-09-01
• Study Completion: 2024-10-01
• Study First Submitted: 2024-12-06
• Study First Submitted QC: 2024-12-11
• Last Update Submitted: 2024-12-11
• Study First Posted: 2024-12-12
• Last Update Posted: 2024-12-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

• age more than 18 years newly diagnosed naive patients with POAG

Exclusion Criteria

• optic nerve lesions other than glaucomatous changes patients with previous glaucoma surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Latanoprost (Xalatan)	Latanoprost (Xalatan)	Group (1) included 23 patients (46 eyes) treated with Latanoprost 0.005 %
Brimonidine 0.2%	Brimonidine 0.2 %	24 patients (48 eyes) received treatment with Brimonidin tartrate 0.2% in group (2)

Primary Outcome Measures

Name	Time	Method
OPTIC NERVE PERFUSION using OCT angiography numerical analysis system presented in %	3 months	perfusion of optic nerve head in patients with primary open angle glaucoma (POAG) using optical coherence tomography angiography (OCTA).

Trial Locations

Locations (1)

Zagazig University; 🇪🇬 Zagazig, Sharkia, Egypt