Long-Term Outcomes of Hypopituitarism Following Gamma Knife Radiosurgery for Pituitary Adenomas
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 137
- 试验地点
- 1
- 主要终点
- Prevalence of new-onset hypopituitarism
研究概览
简要总结
This study aims to assess long-term outcomes of hypopituitarism following gamma knife radiosurgery (GKRS) for pituitary adenomas.
详细描述
Pituitary adenomas (PAs) are one of the most common intracranial neoplasms, accounting for 10-20% of diagnosed brain tumors.
Initial gamma knife radiosurgery (GKRS) can be an alternative treatment for selected NFPA patients with comorbidities, documented growth small tumors, cavernous sinus invasion, or advanced age.
Hypopituitarism is one of the most common complications of radiosurgery (Cordeiro et al., 2018). Long-term follow-up is crucial to assess new pituitary deficits. Typically, hypopituitarism presents within the first 2-4 years after the treatment with radiosurgery, but the risk of pituitary insufficiency increases to up to 80%. Reports on the highest incidence of new-onset hypopituitarism also mentioned the longest follow-up period.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years.
- •Both sexes.
- •Patients treated with gamma knife radiosurgery (GKRS).
排除标准
- •Patients with inadequate endocrine follow-up (<12 months).
- •Patients who had undergone previous radiation therapy.
- •Pituitary insufficiency which presents before gamma knife radiosurgery (GKRS).
- •Patients without visible glands.
结局指标
主要结局
Prevalence of new-onset hypopituitarism
时间窗: 5 years post-procedure
Prevalence of new-onset hypopituitarism will be recorded.
次要结局
未报告次要终点
研究者
Awad Mohamed Hegab
Lecturer of Neurosurgery, Faculty of Medicine, Al-Azhar University, Damietta, Egypt.
Al-Azhar University