Association of TTGA (Tissue Transglutaminase Antibody) and Histopathologic Findings in Thyroidectomy Patients

Not Applicable

• Conditions: Thyroid Fibrosis
• Interventions: Other: Measuring of fibrosis in thyroid specimen and measuring of Anti-tTG in serum samples

• Registration Number: NCT04974255
• Lead Sponsor: Diskapi Yildirim Beyazit Education and Research Hospital

Brief Summary

Gluten sensitivity is the most common auto-immune disease associated with auto-immune thyroiditis. This association is through elevated anti-Tissue transglutaminase (Anti-tTG) levels both in Celiac disease and thyroiditis. In our study we tried to find if there is any correlation in between Anti-tTG and degree of fibrosis in thyroid tissue (Post-operative specimen).

Detailed Description

Most common auto-immune disease associated with Celiac disease is autoimmune thyroiditis. This association in between Celiac disease and aout-immune thyroiditis is related with asymptomatic rise in anti-tTG levels. In our study, we planned to show that if there is any correlation of thyroiditis related fibrosis in thyroid tissue with anti-tTG IgA ( immune-globulin A) and IgG (immune-globulin G).

Study Timeline

• Study Start: 2019-05-01
• Study First Submitted: 2021-05-31
• Status Verified: 2021-07
• Study First Submitted QC: 2021-07-13
• Last Update Submitted: 2021-07-13
• Study First Posted: 2021-07-23
• Last Update Posted: 2021-07-23
• Primary Completion: 2021-07-26
• Study Completion: 2021-07-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 198

Inclusion Criteria

• Thyroiditis patients operated for any indication

Exclusion Criteria

• Patients with known IgA deficiency

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Operated Patients	Measuring of fibrosis in thyroid specimen and measuring of Anti-tTG in serum samples	Measurement of fibrosis degree and Anti-tTG levels

Primary Outcome Measures

Name	Time	Method
Amount of fibrosis in thyroid tissue and measured level of anti-tTG levels in serum	one day after operation	Degree of fibrosis was defined after painting of slides with masson trichrome as absent, mild, moderate semi-quantitatively.
Measurement of Anti-tTG levels in serum	one day after operation	Amount of serum Anti-TG in IU/mL

Trial Locations

Locations (1)

SBU Diskapi Yildirim Beyazit Training and Research Hospital; 🇹🇷 Ankara, Turkey