Comparison of Intraperitoneal administration (giving drug into the abdominal cavity) of Ropivacaine (local anaesthetic) with Dexmedetomidine (sedative) Versus Ropivacaine with Ketamine (sedative) for Post Operative Pain Relief Following Laparoscopic Cholecystectomy
Phase 4
- Conditions
- Health Condition 1: K80- Cholelithiasis
- Registration Number
- CTRI/2019/11/022129
- Lead Sponsor
- CMS and GTB Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients of either gender giving consent for the study and aged 20-55 years belonging to ASA grade I or II scheduled for elective laparoscopic cholecystectomy under general anaesthesia.
Exclusion Criteria
1.Patients with cardiovascular, pulmonary, psychological or neurological diseases
2.Patients who are known to be epileptic
3.Patients who have an increase in intracranial tension
4.Patients with known allergies to the study drugs
5.Patients with abnormalities like heart block, left bundle branch block
6.Patients in whom the procedure will be converted to open cholecystectomy
7.Obese patients (BMI more than or equal to 30)
8.Patients in whom subhepatic drain is inserted after the removal of gall bladder.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time to demand of first dose of rescue analgesia in the three groupsTimepoint: Once, during first 24 hours, when patient complains of pain and NRS is more than or equal to 4
- Secondary Outcome Measures
Name Time Method Any adverse effectsTimepoint: first 24 hours <br/ ><br>;Hemodynamic parameters at the time of extubationTimepoint: Intraoperative, Immediate postoperative, 5 mins, 10 mins, 15 mins, 30 mins, 1h, 1 h 30 mins, 2h, 3h, 4h, 5h, 6h, 7h, 8h <br/ ><br>;Post-operative pain using Numeric Rating Scale (NRS)- Static and Dynamic.Timepoint: 30 min, 1 h, 2h, 3h, 4 h, 6h, 8 h, 12 h, 18 h and 24 h postoperatively;Time to extubation. <br/ ><br>Timepoint: Once, at the time of tracheal extubation;To assess the quality of post operative pain using Revised American Pain Society Patient Outcome Questionnaire.Timepoint: After 24 hours;Total dose of rescue analgesia requiredTimepoint: First 24 hours