Structural and Functional Brain Reorganization in Neuropathic Pain: Basal State of Local Cerebral Blood Flow and Functional Connectivity

Not Applicable

Terminated

• Conditions: Neuropathic Pain
• Interventions: Radiation: MRI scan

• Registration Number: NCT02858466
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Neuropathic pain is a medical condition involving allodynia (painful perceptions in response to stimuli that normally are not) and spontaneous pain (occurring at rest, without stimulation).

This pain is secondary to nervous system injury affecting the sensory system. The lesion is either at the nerve endings of the spinal cord or brain.

It induces a loss of sensitivity and likely reorganization of brain activity that are causing pain and which are the subject of this study.

Previous studies in functional neuroimaging has focused on brain areas activated during allodynic stimuli compared to non-painful stimuli. The abnormalities have been reported, but it was not possible to conclude formally. The authors failed to assess the part of the effect of the loss of sensory afferents (deafferentation) and the basal brain function.

Indeed, the operation without any sensory stimulation is not known yet is the initial level of activity which is the benchmark for studying brain function during stimulation. The objective of this study is to understand what are the cortical systems of allodynic dysfunctional in patients compared with controls at baseline.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-03-25
• Study First Submitted: 2016-07-25
• Study First Submitted QC: 2016-08-03
• Study First Posted: 2016-08-08
• Primary Completion: 2019-03-22
• Study Completion: 2019-03-22
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-24
• Last Update Posted: 2020-09-28

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 68

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
control group	MRI scan	MRI scan
peripheric nervous lesion	MRI scan	MRI scan
medullar or encephalic lesion	MRI scan	MRI scan

Primary Outcome Measures

Name	Time	Method
cerebral blood flow	at baseline	quantified with MRI scan

Secondary Outcome Measures

Name	Time	Method
rate of grey matter	at baseline	difference between groups
connection of the networks	at baseline	Determine if connection of the networks is different between patients and controls.; Measured with MRI scan.
cortical loss	at baseline	Assess the cortical loss of the patient group compared to controls. Measured with MRI scan.
structure of the networks	at baseline	Determine if structure of the networks is different between patients and controls.; Measured with MRI scan.

Trial Locations

Locations (1)

CHU de SAINT-ETIENNE; 🇫🇷 Saint-etienne, France