Structural and Functional Brain Reorganization in Neuropathic Pain. Influences of the Loss of Sensitivity and the Atrophy Cortical on Activations Due to Stimulation Allodynic

Not Applicable

Terminated

• Conditions: Neuropathic Pain
• Interventions: Other: stimulation on painful area (area allodynic); Other: same stimulation on non-painful area; Radiation: MRI scan

• Registration Number: NCT02858479
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Neuropathic pain is a medical condition involving allodynia (painful perceptions in response to stimuli that normally are not) and spontaneous pain (occurring at rest, without stimulation).

This pain is secondary to nervous system injury affecting the sensory system. The lesion is either at the nerve endings of the spinal cord or brain. It induces a loss of sensitivity and reorganization of brain activity.

Previous studies in functional neuroimaging have focused on brain areas activated during allodynic stimuli compared to non-painful stimuli. The abnormalities have been reported, but it was not possible to conclude formally.

The objective of this study is to understand the brain dysfunction that induces allodynic pain considering the deafferentation of each patient and possible cortical losses.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-03-25
• Study First Submitted: 2016-08-01
• Study First Submitted QC: 2016-08-03
• Study First Posted: 2016-08-08
• Primary Completion: 2019-02-11
• Study Completion: 2019-02-11
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-24
• Last Update Posted: 2020-09-28

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

• with neuropathic pain
• in the case of central lesions, the lesion must be unique and small
• treatment not stable opioid for one week
• consent signed

Exclusion Criteria

• severe psychiatric history
• presence of an evolutive lesion, expansive, cancerous or tumorous underlying
• patient needing of opioid therapy
• contraindication at MRI scan

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
patients with pain allodynic peripheral	MRI scan	-
patients with pain allodynic peripheral	same stimulation on non-painful area	-
patients with pain allodynic central	MRI scan	-
patients with pain allodynic central	stimulation on painful area (area allodynic)	-
patients with pain allodynic central	same stimulation on non-painful area	-
patients with pain allodynic peripheral	stimulation on painful area (area allodynic)	-

Primary Outcome Measures

Name	Time	Method
gray matter rate	at baseline	gray matter rate measured with MRI scan
the deafferentation rate	at baseline	the deafferentation rate measured with thermo-test

Secondary Outcome Measures

Name	Time	Method
Analysis pain	at baseline	Measured by visual analogue scale (0 to 10)

Trial Locations

Locations (1)

CHU de SAINT-ETIENNE; 🇫🇷 Saint-etienne, France