Effect of Gastric Bypass Surgery on Pancreatic Islet and Incretin Function - Follow-up Study
- Conditions
- Obesity
- Registration Number
- NCT02161666
- Lead Sponsor
- Hvidovre University Hospital
- Brief Summary
To examine pancreatic islet function and incretin function during intravenous and oral stimulation \>2 years after gastric bypass surgery in patients with normal glucose tolerance. We hypothesize that islet cell and incretin function is enhanced in response to oral, but not intravenous, stimulation - i.e. incretin released from the gut in response to oral stimulation play a key role for the enhanced islet function after gastric bypass surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 7
- Participation in previous study (NCT01559779)
- Pregnancy/lactation
- Major chronic disease develop since previous examination with possible impact on outcomes
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in islet cell function from baseline (preoperatively) >24 months Change in insulin and glucagon secretion during oral and intravenous stimulation after gastric bypass
- Secondary Outcome Measures
Name Time Method Change in glucose tolerance during oral glucose tolerance test >24 months Fasting, peak and nadir glucose during oral glucose tolerance test
Arterio-venous glucose difference during oral glucose tolerance test after gastric bypass >24 months Differences in arterial and venous plasma glucose during oral glucose stimulation
Trial Locations
- Locations (1)
Hvidovre University Hospital
🇩🇰Hvidovre, Danmark, Denmark