Impact of Nocturnal Blood Pressure Dipping on Ventricular Repolarization in Hypertensive Patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 140
- 主要终点
- Effect of nocturnal BP dipping on ECG markers of ventricular repolarization
研究概览
简要总结
The primary aim is to determine whether non-dipping status is associated with adverse repolarization markers and impaired myocardial mechanics compared to dipper hypertensive patients. Secondary analyses will compare these findings among resistant vs. non-resistant and controlled vs. uncontrolled hypertensive groups. This study may provide new insights into the prognostic significance of blood pressure dipping patterns in hypertensive patients.
详细描述
Hypertension is a highly prevalent chronic condition and one of the leading causes of cardiovascular disease worldwide. It is associated with structural and electrical remodeling of the heart, including left ventricular hypertrophy, myocardial fibrosis, and impaired ventricular repolarization. These changes predispose patients to arrhythmias and adverse cardiovascular outcomes.
A physiological decline in blood pressure during nighttime, known as nocturnal dipping, represents a normal circadian rhythm and is considered a favorable prognostic sign. However, many hypertensive patients fail to show this nocturnal decline (non-dippers), which may indicate heightened sympathetic activity, impaired recovery during sleep, and increased cardiovascular risk. Identifying the impact of dipping status on cardiac electrical and mechanical function could therefore have important clinical value.
This study is designed as an observational prospective registry enrolling adult patients with essential hypertension. All participants will undergo 24-hour ambulatory blood pressure monitoring to determine dipping pattern, standard 12-lead electrocardiography for analysis of repolarization markers such as QTc, QT dispersion, and Tp-Te interval, and comprehensive transthoracic echocardiography including strain imaging to assess myocardial mechanics. Laboratory tests including electrolytes and renal function will also be performed to exclude confounding factors.
The primary objective is to evaluate the effect of nocturnal blood pressure dipping on ventricular repolarization parameters and echocardiographic findings in hypertensive patients. Secondary objectives include assessing differences between resistant and non-resistant hypertension as well as controlled and uncontrolled hypertension groups. The study is expected to provide novel insights into the prognostic role of dipping status and its association with electrical and functional cardiac abnormalities.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults ≥18 years old
- •Diagnosed with essential hypertension
- •Completed 24-hour ambulatory blood pressure monitoring (ABPM)
- •Availability of good-quality 12-lead ECG
- •Availability of good-quality transthoracic echocardiography
排除标准
- •Body mass index (BMI) > 34.9 kg/m²
- •Atrial fibrillation or atrial flutter
- •Use of QT-prolonging medications
- •End-stage renal disease or liver failure
- •Bundle branch block or presence of pacemaker
- •Prior coronary revascularization (PCI or CABG)
- •Significant electrolyte imbalance
结局指标
主要结局
Effect of nocturnal BP dipping on ECG markers of ventricular repolarization
时间窗: At enrollment
Evaluation of QTc, QT dispersion, and Tp-Te interval in dipper vs. non-dipper hypertensive patients, correlated with echocardiographic changes
次要结局
- Repolarization and echocardiographic changes in resistant vs. non-resistant hypertension(At enrollment)
研究者
Amr Abdelwahab Hussein Ahmed
Dr
Assiut University