Using two different doses of bupivacaine for spinal block.

• Conditions: anaesthesia for orthopedic surgery of lower limb fractures:

• Registration Number: CTRI/2013/02/003382
• Lead Sponsor: University College of Medical Sciences and GTB Hospital

Brief Summary

Epidural volume extension is a commonly practiced anaesthetic technique, used following a deliberately reduced or inadequate dose of the intrathecal drug. Whether reduction in the intrathecal doses with a consequently decreased spread in cerebrospinal fluid can limit the epidural volume extension induced cephalic spread, and hence the sensory block augmentation, has not been evaluated till date.

The present research plans to investigate whether the dose of intrathecal plain bupivacaine determines the epidural volume extension induced sensory block augmentation. The aim is to assess the application of epidural volume extension to two clinically used doses of intrathecal plain bupivacaine. The null hypothesis is that there is no difference in epidural volume extension induced dermatomal increase in sensory block following its application to intrathecal injection of 5 mg and 10 mg plain bupivacaine.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01-10
• Last Update Posted: 2016-09-28

Recruitment & Eligibility

• Status: Other
• Sex: Male
• Target Recruitment: 24

Inclusion Criteria

consenting adult male patients of ASA physical status I or II with body weight between 50-70 kg and height of 150-180 cm undergoing orthopedic surgery for fracture in lower limb using combined spinal epidural anaesthesia.

Exclusion Criteria

Patients with diabetes mellitus, history of spinal disease or coagulation abnormalities, skin infection at site of injection and other contraindications to combined spinal epidural anaesthesia including sensitivity to local anesthetics.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
dermatomal increase in maximum sensory block produced by epidural volume extension	Every 2 minutes, the sensory level will be assessed till 3 consecutive identical readings are obtained (before and after the epidural volume extension).

Secondary Outcome Measures

Name	Time	Method
motor blockade	same as sensory level monitoring to attain grade of maximum motor block.

Trial Locations

Locations (1)

Dept of Anaesthesiology and Critical Care University College of Medical Sciences and GTB Hospital; 🇮🇳 East, DELHI, India

Dept of Anaesthesiology and Critical Care University College of Medical Sciences and GTB Hospital

🇮🇳East, DELHI, India

Asha Tyagi

Principal investigator

9818606404

drashatyagi@gmail.com