Evaluation of aortic elastic properties in the long-term follow-up of surgical and catheter interventional closure of the persistent ductus arteriosus

• Conditions: 10007510; persistent ductus arteriosus; Patent ductus arteriosus; patent vessel between aorta and lung artery

• Registration Number: NL-OMON29770
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Diagnosis of PDA or MARFAN, > 12 year

Exclusion Criteria

1. Hemodynamically relevant residual cardiac anomalies
2. Genetic syndromes other than MARFAN
3. Contraindication against MRI-scanning (arrhythmias, pacemaker implantation, claustrophobia)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>MRI-scanning:<br /><br>difference in aortic distensibility between patients and controls.<br /><br><br /><br>Genetic testing:<br /><br>presence of a predisposing mutation known to be associated with inheritable<br /><br>aortic dissection and/or PDA.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>