Study of clotting of blood using thromboelastography in pregnant patients with pre-eclampsia

Not Applicable

• Conditions: Health Condition 1: O14- Pre-eclampsia

• Registration Number: CTRI/2021/02/030965
• Lead Sponsor: ady hardinge medical college

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Age >18 years.

Third trimester(>=32 weeks of gestation) patients with diagnosed pre-eclampsia undergoing Caesarean delivery.

Exclusion Criteria

Patients prescribed preoperative unfractionated heparin,oral anticoagulants or receiving magnesium therapy.

Patients with a history of deep vein thrombosis,more than two abortions and smoking.

Patients with hereditary thrombophilia or Anti phospholipid antibody syndrome (APLA).

Patients with sepsis.

Patients with major blood loss during surgery or requiring postoperative ventilation.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Percentage of pre-eclamptic patients with deranged thromboelastographic parameters 24 hours post operatively.Timepoint: pre delivery,24 hour and 5th day post caesarean delivery

Secondary Outcome Measures

Name	Time	Method
Thromboelastographic parameters (Mean ± SD) preoperatively, 24 hours and 5th day postoperatively in patients with pre-eclampsia after Caesarean delivery. <br/ ><br>Correlation between coagulation parameters (platelet count, PT, INR, aPTT) with Maximum amplitude, Reaction time, Thrombogenic Potential Index and Coagulation Index; and D-dimer and bleeding time with Reaction time, Thrombogenic Potential Index and Coagulation Index preoperatively and 24 hours postoperatively.Timepoint: pre delivery,24 hour and 5th day post caesarean delivery