Bleeding and clotting complications in patients having liver surgery
Not Applicable
Completed
- Conditions
- iver resectionBleedingThrombosisEndothelial FunctionLiver resectionBlood - Clotting disordersCancer - Liver
- Registration Number
- ACTRN12613000802707
- Lead Sponsor
- Dr Megan L Allen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Adult patients undergoing hepatic resection for malignancy
Exclusion Criteria
Refusal
Clinical indication for anticoagulation perioperatively (except aspirin)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identify predictive thrombogenic biomarkers, to assess changes throughout the perioperative period in patients undergoing hepatic resection.<br><br>Biomarkers will include: Coagulation profile (APTT, PT, INR, Fibrinogen, D-dimer), Thromboelastograph (TEG - Registered Trademark), vWF, FVIIIc, TM, TATC, PF1 + 2, Fibrin monomers<br><br>Detection of bleeding and clotting events will be by routine clinical investigations directed by the treating team (observation, ultrasonography, CT scanning etc)[Day of surgery to day 3 post surgery]
- Secondary Outcome Measures
Name Time Method Determine the temporal pattern of thromboembolism and bleeding events throughout the perioperative period for hepatic resection surgery<br><br>Detection of bleeding and clotting events will be by routine clinical investigations directed by the treating team if indicated (observation, ultrasonography, CT scanning etc)[Day of surgery until 6 weeks post surgery];Develop a thromboembolism risk-model from clinical and thrombogenic biomarkers, for prospective validation and incorporation into risk-targeted thromboprophylaxis guidelines appropriate for hepatic resection [Day of surgery until 6 weeks post surgery];Investigate endothelial function in patients undergoing hepatic resection for cancer<br><br>Assessment will involve the use of the EndoPAT non-invasive finger probe[Day of surgery until day 3 post surgery]