CTRI/2025/08/093166尚未招募不适用
Short- and Long-Term Effects of Aerobic, Resistance, and Combined Forms of Exercise on Tissue Adaptability and Hypertension in Post-Menopausal Women
Aman Navneet Kaur1 个研究点 分布在 1 个国家目标入组 144 人开始时间: 2025年9月15日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 144
- 试验地点
- 1
- 主要终点
- 1.Systolic and Diastolic Blood Pressure
研究概览
简要总结
This PhD thesis is a randomized comparative trial aimed at evaluating the short- and long-term effects of aerobic, resistance, and combined exercise training on cardiovascular health and functional capacity in postmenopausal women aged 50–65 with stage 1 hypertension and prediabetes. A total of 144 participants will be randomly assigned to one of the three exercise modalities, with interventions lasting 12 weeks and assessments conducted at baseline, 4 weeks, and 12 weeks. Outcomes will include blood pressure, arterial stiffness, and functional performance measures such as walking tests, flexibility, and balance. By directly comparing these exercise approaches, the research seeks to identify the most effective non-pharmacological strategy for mitigating cardiovascular risk factors and improving quality of life during the postmenopausal transition, addressing a significant gap in existing literature.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- None
入排标准
- 年龄范围
- 50.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- Female
入选标准
- •Postmenopausal Status: Natural Menopause: Absence of menstruation for 12 months or more (World Health Organization, 2022; North American Menopause Society, 2023).
- •Age Range: Women aged between 50 and 65 years (World Health Organization, 2022; North American Menopause Society, 2023; American Heart Association, 2022) Medication Use: Participants may be on medication, but their condition must be stable with medical clearance from a healthcare provider.
- •Body Mass Index (BMI) BMI between 18.5 and 29.9 kg/m² (Based on WHO classification).
- •Hypertension Status (Based on American Heart Association Guidelines) Stage 1 Hypertension: Systolic Blood Pressure: 130–139 mmHg Diastolic Blood Pressure: 80–89 mmHg New York Heart Association (NYHA) Classification for Heart Failure Risk: Stage A: At risk for heart failure but with no symptoms or structural/functional heart disease.
- •Class I: No symptoms and no limitation in ordinary physical activity.
- •Prediabetes (Based on American Diabetes Association Criteria) Participants must meet at least one of the following criteria for prediabetes: A1C: 5.7%–6.4% Fasting Blood Glucose (FBS): 100–125 mg/dL Oral Glucose Tolerance Test (OGTT): 140–199 mg/dL.
排除标准
- •Cardiorespiratory Disease Includes any chronic heart disease such as heart failure inability of the heart to pump sufficient blood chronic obstructive pulmonary disease also called COPD coronary artery disease narrowing or blockage of coronary arteries or pulmonary hypertension increased blood pressure in the arteries of the lungs Renal Pulmonary Skin and Gynecological Disorders Renal Disorders Any chronic kidney disease or renal failure acute or chronic impacting kidney function Pulmonary Disorders Conditions like asthma emphysema chronic bronchitis or any form of severe respiratory disease Skin Disorders Severe dermatological conditions such as psoriasis eczema or chronic wounds or infections that could interfere with exercise or pose health risks Gynecological Disorders Any condition affecting the female reproductive system including but not limited to endometriosis fibroids pelvic inflammatory disease or cervical cancer Metabolic and Neuromuscular Disorders Metabolic Disorders Conditions such as diabetes mellitus type one and type two hyperthyroidism hypothyroidism and metabolic syndrome a combination of hypertension high blood sugar excess body fat around the waist and abnormal cholesterol levels Neuromuscular Disorders Conditions affecting the muscles and nervous system such as multiple sclerosis muscular dystrophy or amyotrophic lateral sclerosis also called ALS Haematological and Neurological Disorders Haematological Disorders Disorders like anemia low red blood cell count leukemia blood cancer or any condition affecting blood clotting such as hemophilia or thrombocytopenia Neurological Disorders Conditions affecting the nervous system such as epilepsy stroke Parkinsons disease or dementia Fractures in the Last Three Months Any bone fractures such as fractures of the arms legs ribs or spine that occurred in the last three months due to the potential for further injury during physical activity Ovarian and Breast Cancer Ovarian Cancer or Breast Cancer either current or in remission especially if diagnosed within the past five years as these conditions require specific medical management and may be contraindicated for certain physical activities Hormone Replacement Therapy Within the Past One to Two Years Women who have undergone hormone replacement therapy HRT within the past one to two years for symptoms of menopause as HRT can alter the bodys hormonal balance and affect the response to exercise Surgical Procedures Within the Past One to Two Years Women who have undergone any major surgical procedures such as abdominal joint replacement or gynecological surgeries in the last one to two years which could interfere with their ability to engage in physical activity or pose health risks during exercise Type One and Type Two Diabetes Mellitus Women with type one diabetes insulin dependent or type two diabetes insulin resistance who have poorly controlled blood sugar levels as this condition requires careful management during physical activity and may increase the risk of complications like hypoglycemia or cardiovascular issues.
结局指标
主要结局
1.Systolic and Diastolic Blood Pressure
时间窗: Baseline | 4 weeks | 12 weeks
2.Functional Status [Walking Distance (ms), Walking Time (s), Walking Speed (ms/s)]
时间窗: Baseline | 4 weeks | 12 weeks
3.Pulse Wave Velocity
时间窗: Baseline | 4 weeks | 12 weeks
次要结局
未报告次要终点
研究者
Aman Navneet Kaur
Department of Physiotherapy, Lovely Professional University
研究点 (1)
Loading locations...
相似试验
尚未招募
不适用
use of assisted Treadmill training and Strengthening exercises to improve walking and brain recovery in Stroke patients.Diseases of the nervous system, (2) ICD-10 Condition: G460||Middle cerebral artery syndrome, (3) ICD-10 Condition: G461||Anterior cerebral artery syndrome, (4) ICD-10 Condition: G462||Posterior cerebral artery syndrome, (5) ICD-10 Condition: G467||Other lacunar syndromes,CTRI/2025/02/081081Sri Devaraj Urs Academy of Higher Education and Research Center, Kolar, Karnataka,563101 .23
招募中
不适用
Effects of cardio and strength exercises on health indicators in people with a family history of high blood pressureCTRI/2026/02/103848Centre for Physiotherapy and Rehabilitation Sciences44
尚未招募
不适用
Effects of Resistance and Dual-Task Training on Physical, Oculomotor, and Executive Functions in Older Adults With MCINCT07278141Universidad Santo Tomas, Chile66
已完成
不适用
Effects of Short-Term Resistance Training on Diaphragm Thickness, Hepatic Fat Density, and Quality of Life in Healthy Older MenFatty LiverNCT07449767Gümüşhane Universıty30
已完成
不适用
Study on the Effects of Unilateral Resistance Training on Lower Limb Muscle Strength and Symmetry After Anterior Cruciate Ligament Reconstruction SurgeryNCT07271173Peking University Third Hospital48