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RECOVER-NEURO: Platform Protocol to Measure the Effects of Cognitive Dysfunction Interventions on Long COVID Symptoms

Not Applicable
Completed
Conditions
Long COVID
Long Covid19
Long Covid-19
Interventions
Other: BrainHQ/Active Comparator Activity
Other: BrainHQ
Other: PASC CoRE
Device: tDCS-active
Device: tDCS-sham
Registration Number
NCT05965752
Lead Sponsor
Duke University
Brief Summary

This platform protocol is designed to be flexible so that it is suitable for a wide range of settings within health care systems, for remote settings, and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans.

This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating potential interventions for PASC-mediated cognitive dysfunction. The hypothesis is that PASC associated dysfunction in cognitive domains, such as executive function and attention, may be improved by interventions that selectively focus on enhancing those domains.

Detailed Description

Participants will be randomized to one of the intervention appendices that are actively enrolling at the time of randomization. Intervention appendices may be added or removed according to adaptive design and/or emerging evidence. Various interventions will be studied.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
328
Inclusion Criteria

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

  1. ≥ 18 years of age at the time of enrollment

  2. PROMIS-Cog T-score < 40

  3. Previous suspected, probable, or confirmed SARS-CoV-2 infection, as defined by the Pan American Health Organization

    Suspected case of SARS-CoV-2 infection - three options, A through C:

    A. Met clinical OR epidemiological criteria:

    a. Clinical criteria: Acute onset of fever AND cough (influenza-like illness) OR Acute onset of ANY THREE OR MORE of the following signs or symptoms: fever, cough, general, weakness/fatigue, headache, myalgia, sore throat, coryza, dyspnea, nausea, diarrhea, anorexia; b. Epidemiological criteria: Contact of a probable or confirmed case or linked to a COVID-19 cluster;

    B. Presented acute respiratory infection with history of fever or measured fever of ≥ 38°C and cough, with onset within the last 10 days, and who requires hospitalization; or

    C. Presented with no clinical signs or symptoms, NOR meeting epidemiologic criteria with a positive professional use or self-test SARS-CoV-2 Antigen-Rapid Diagnostic Test.

    Probable case of SARS-CoV-2 infection, defined as having met clinical criteria above AND was a contact of a probable or confirmed case or was linked to a COVID-19 cluster.

    Confirmed case of SARS-CoV-2 infection - two options, A through B:

    A. Presented with a positive nucleic acid amplification test, regardless of clinical criteria OR epidemiological criteria; or

    B. Met clinical AND/OR epidemiological criteria (See suspected case A.a.), with a positive professional use or self-test SARS-CoV-2 Antigen-Rapid Diagnostic Test.

    * Suspected and probable cases will only be allowed if they occurred before May 1, 2021, and will be limited to 10% of the study population. Otherwise, confirmed cases are required.

  4. Cognitive dysfunction symptoms following a SARS-CoV-2 infection that have persisted for at least 12 weeks and are still present at the time of consent

  5. Fluent in English or Spanish language

  6. Willing and able to provide informed consent, complete the intervention, complete the intervention assessments, and return for all of the necessary follow-up visits

Exclusion Criteria

An individual who meets any of the following criteria will be excluded from participation in this study:

  1. Prior or active unstable or progressive major psychiatric or neurologic condition that would not show improvement and could hide treatment effect and is not related to SARS-CoV-2 infection, at the investigator's discretion, including, but not limited to, the following examples:

    a. Progressive neurodegenerative disease, such as Alzheimer's disease, Parkinson's disease, etc.

    b. Past traumatic brain injury occurrence still associated with active post-concussive symptoms c. Uncontrolled seizure disorder, such as having at least one seizure in the last year that is adjudicated by clinical judgement d. Post-stroke deficits that may interfere with assessment, such as language or communication difficulties, aphasia, etc.

    e. Formal thought disorders, such as schizophrenia, etc. f. Any neuropsychiatric or neurologic disorder uncontrolled for the previous six months or that may interfere with assessment, at discretion of the investigator

  2. Known prior diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome, not related to SARS-CoV-2 infection

  3. Known active acute SARS-CoV-2 infection ≤ 4 weeks from consent

  4. Current use of symptomatic therapies including prescribed or illicit stimulants, amantadine, N-methyl-D-aspartate receptor antagonists (e.g., memantine, dissociative drugs)

  5. Current use of a stimulant for treating any PASC-related symptom

  6. Current diagnosis of alcohol and substance use disorders

    a. Prior use disorders acceptable if abstinence achieved and maintained for at least 12 months before study enrollment

  7. Insufficient visual, auditory, and motor function to participate in intervention and assessments

  8. Known pregnancy

  9. Current or recent use (within the last 2 months) of intervention*

  10. Known allergy/sensitivity/hypersensitivity to components of the intervention or comparator*

  11. Currently receiving/using intervention from another clinical trial, such as another RECOVER trial

  12. Any condition that would make the participant, in the opinion of the investigator, unsuitable for the study

    1. The site investigator has the discretion to determine whether a participant is too cognitively impaired to participate and should instead be referred for clinical evaluation.

Exclusions specific to intervention appendices are listed in each appendix.

* Relevant if only one intervention appendix is open at the time of enrollment, though exclusion may be qualified in the appendix. If multiple intervention appendices are open, a participant may be excluded from any intervention appendix based on contraindications listed in the intervention appendix, current use of intervention, or known allergy/sensitivity/hypersensitivity and still remain eligible for the remaining intervention appendices.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
BrainHQ Active ComparatorBrainHQ/Active Comparator Activity5 sessions/week at 30 min/session
BrainHQBrainHQ5 sessions/week at 30 min/session
Brain HQ + tDCS-activeBrainHQ2.0 mA stimulation delivered for 30 min during each BrainHQ session
BrainHQ + PASC CoREBrainHQBrainHQ plus 9 group sessions at 1.5 hr/session and 3 individual sessions at 1 hr/session
BrainHQ + PASC CoREPASC CoREBrainHQ plus 9 group sessions at 1.5 hr/session and 3 individual sessions at 1 hr/session
Brain HQ + tDCS-activetDCS-active2.0 mA stimulation delivered for 30 min during each BrainHQ session
Brain HQ + tDCS-shamBrainHQInactive stimulation delivered for 30 min during each BrainHQ session
Brain HQ + tDCS-shamtDCS-shamInactive stimulation delivered for 30 min during each BrainHQ session
Primary Outcome Measures
NameTimeMethod
Total number of participants enrolled in each Appendix160 Days

Total number of participants enrolled in each Appendix will be reported. Appendix-specific outcome measure data will be reported under the associated NCT#

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (24)

Ronald Reagan UCLA Medical Center

🇺🇸

Los Angeles, California, United States

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

🇺🇸

Torrance, California, United States

Rush University Medical Center

🇺🇸

Chicago, Illinois, United States

West Virginia Clinical and Translational Science Institute

🇺🇸

Morgantown, West Virginia, United States

North Shore University Health System/Evanston Hospital

🇺🇸

Skokie, Illinois, United States

Boston Medical Center

🇺🇸

Boston, Massachusetts, United States

Case Western Reserve University

🇺🇸

Cleveland, Ohio, United States

University of Texas Health Science Center at Houston

🇺🇸

Houston, Texas, United States

University of Texas Health Science Center at San Antonio

🇺🇸

San Antonio, Texas, United States

University of Utah Hospitals and Clinics

🇺🇸

Salt Lake City, Utah, United States

University of Washington

🇺🇸

Seattle, Washington, United States

University of Florida College of Medicine Jacksonville

🇺🇸

Jacksonville, Florida, United States

Dartmouth-Hitchcock Medical Center

🇺🇸

Lebanon, New Hampshire, United States

Banner University Medical Center Phoenix

🇺🇸

Phoenix, Arizona, United States

Banner University Medical Center- Tucson

🇺🇸

Tucson, Arizona, United States

Stanford University

🇺🇸

Stanford, California, United States

OSF Healthcare

🇺🇸

Peoria, Illinois, United States

Jadestone Clinical Research

🇺🇸

Silver Spring, Maryland, United States

Beth Israel Daeconess Medical Center

🇺🇸

Boston, Massachusetts, United States

Icahn School of Medicine at Mount Sinai

🇺🇸

New York, New York, United States

University of Vermont

🇺🇸

Burlington, Vermont, United States

NYU Langone Health/Brooklyn Hospital

🇺🇸

Brooklyn, New York, United States

University of Colorado Anschutz Medical Campus

🇺🇸

Aurora, Colorado, United States

University of Kansas Medical Center

🇺🇸

Kansas City, Kansas, United States

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