The comparative study of voice quality improvement according to ilaprazole administration on laryngopharyngeal reflux disease patients with voice change
- Conditions
- Diseases of th respiratory system
- Registration Number
- KCT0004179
- Lead Sponsor
- Koera University Guro Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 140
(1) Those who don't lack decision-making capacity, with the age of between 19 and 75
(2) Those suffering from voice disorder with the score of Reflux Symptom index (RSI) and Reflux Finding score (RFS) higher than 13 and 7 point.
(3) Those who agree to participate in this clinical trial voluntarily.
(1) Those sensitive to class of Ilaprazole (Proton pump inhibitor)
(2) Those with history of malignant tumor
(3) Those with need to take Warfarin, Coumarin, Aspirin(higher then 325mg/d) or steroid consistently.
(4) Those with history of surgery or treatment due to Gastroesophageal reflux disease (GERD)
(5) Those with history of Gastric acid suppression
(6) Those with history of significant surgery which has impact on Gastric acid secretion
(7) Those taking Gastric acid suppression medicine
(8) Mental illiness patient, alcohol addictor or those with history of drug abuse
(9) Pregnant and lactating women
(10) Childbearing women (Menopausal women who are amenorrheic for at least 12 months are considered to be non-childbearing women.)
(11) Those who participated in other clinical trial within 30 days before screening
(12) Those who specialize in voice
(13) Those with other observed laryngopharynx disease except laryngopharyngeal reflux disease
(14) Those who are judged to be improper for this clinical trial
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Voice handicap index;Multi-dimensional voice program, MDVP
- Secondary Outcome Measures
Name Time Method Reflux Finding Score;Reflux Symptom Score