临床试验/NCT01233115

NCT01233115已完成不适用

LOC387715/HTRA1 Variants and the Response to Combined Photodynamic Therapy With Intravitreal Bevacizumab in Polypoidal Choroidal Vasculopathy

Kyungpook National University Hospital1 个研究点分布在 1 个国家目标入组 70 人开始时间: 2010年10月最近更新: 2011年8月30日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: Kyungpook National University Hospital
入组人数: 70
试验地点: 1
主要终点: Best-corrected visual acuity

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study is to investigate whether there is an association of the LOC387715/HTRA1 variants with response to treatment with combined photodynamic therapy and intravitreal bevacizumab for patients with polypoidal choroidal vasculopathy.

详细描述

This is a retrospective cohort study comprised of 70 eyes being treated for polypoidal choroidal vasculopathy with combined photodynamic therapy and intravitreal bevacizumab injections. Patients were genotyped for the LOC387715 (rs10490924) and the HTRA1 gene polymorphism (rs11200638).

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Retrospective

入排标准

年龄范围: 60 Years 至 80 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•patients older than 60 years of age at onset
•polyp-like terminal aneurysmal dilations with or without branching vascular networks in indocyanine green angiography (ICGA) and subretinal reddish-orange protrusions corresponding to polyp-like lesions
•patients who had combined photodynamic therapy and intravitreal bevacizumab injections, and followed up for more than 12 months after the first treatment

排除标准

•patients with retinal or choroidal diseases including pathologic myopia, angioid streaks, idiopathic choroidal neovascularization (CNV), presumed ocular histoplasmosis, and other secondary CNV
•patients who refused genotypic analyses

结局指标

主要结局

Best-corrected visual acuity

时间窗: up to 12 months

Best-corrected visual acuity (BCVA) using the Snellen chart was evaluated including BCVA up to 12 months

次要结局

Angiographic characteristics(up to 12 months)

研究者

发起方

Kyungpook National University Hospital

申办方类型

Other

责任方

Principal Investigator

主要研究者

Dong Ho Park

clinical professor

Kyungpook National University Hospital

研究点 (1)

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