Genotype-Phenotype-Correlation of Drug-Metabolising Enzymes
- Conditions
- Drug metabolism of healthy participants
- Registration Number
- DRKS00017626
- Lead Sponsor
- niversitätsklinikum Schleswig-Holstein (UKSH)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 200
Age 18-55 years
Laboratory values in normal range: Elektrolytes (Na, K, Cl, Ca), Creatinin, Urea, Albumin, Hemoglobin, Hematokrit, INR <1.5
No severe pathologic findings in the cardiovascular, renal, pulmonal, hematopoetical, hepatic or neuronal system
No acute pathology during screening
Informed consent
Known hypersensitivity to the probe drug cocktail
Laboratory values outside reference range (as judged by the investigator)
Pregnancy
Contraception with hormonal contraceptives
Drug use within 3 days before phenotyping
Expected non-compliance
Other absolute and relative contraindications of the probe drugs
Other conditions that might render the subject inappropriate for this trial (as judged by the investigator)
Concurrent participation in another clinical trial
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Metabolic ratios of probe drugs and their metabolites (Blood sample 5 hours after application of drug cocktail or during 8 hours after application as urine collection.)
- Secondary Outcome Measures
Name Time Method Genome-wide association study of metabolic ratios