GENETIC DETERMINANTS OF MONOAMINE METABOLITE LEVELS IN HUMAN CEREBROSPINAL FLUID
Completed
- Conditions
- major depressionsadness10027946
- Registration Number
- NL-OMON38098
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 1000
Inclusion Criteria
Military personnel and civilians referred for surgical procedures under spinal anesthesia whose four grandparents were born in The Netherlands will be included.
Exclusion Criteria
Exclusion criteria are: age < 18 and > 58 years old and the use of benzodiazepines shortly before entering the operating theatre.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Levels of HVA, 5-HIAA and MHPG in CSF will be tested for association with a set<br /><br>of single nucleotide polymorphisms (SNPs). The DNA region of interest is the<br /><br>chromosome region that is homologous to the region that was recently found to<br /><br>be linked with MAM levels in vervet monkeys. Once identified, the effect of<br /><br>associated polymorphisms on RNA expression of monoamine genes will be<br /><br>investigated. MAM levels and associated genotypes will be related to specific<br /><br>behavioral traits, as assessed through validated questionnaires. </p><br>
- Secondary Outcome Measures
Name Time Method <p>As a secondary parameter, we will measure CSF amino acid concentrations and<br /><br>correlate these quantitatively to candidate genotypes and behavioral traits as<br /><br>assessed with the abovementioned questionnaires.</p><br>