Identifying genetic and metabolic risk factors for mild non-specific mental retardation and borderline intellectual functioning in parent offspring trios.
Completed
- Conditions
- 1. mild non-specific mental retardation and borderline intelligence 2. mild intellectual disability10029299
- Registration Number
- NL-OMON34844
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 3000
Inclusion Criteria
1. borderline intellectual functioning (IQ 70-85) or mild mental retardation (IQ 50-70)
2. age 4-18 years
3. parents are available (at least one) and capable of communication in the Dutch language
Exclusion Criteria
1. major congenital malformation
2. suspicion of a syndrome based on physical examination and/or history, judged by a clinical geneticist
3. a known cause for the mild a-specific MR or borderline intellectual functioning
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- Genetic variation (Single Nucleotide Polymorphisms, SNPs).<br /><br>- Metabolite concentration in urine and plasma.<br /><br>- IQ as measured by an IQ test.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Attention and social skills, abnormal child behaviour scores, daily functioning<br /><br>will be measured using questionnaires. </p><br>