Multi-Ethnic New Zealand Study of Acute Coronary Syndromes

Not Applicable

Recruiting

• Conditions: Acute coronary syndrome; Cardiovascular - Coronary heart disease; Human Genetics and Inherited Disorders - Other human genetics and inherited disorders

• Registration Number: ACTRN12615000676516
• Lead Sponsor: The University of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-06-30
• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

For cases - patients who are admitted to hospital with first time acute coronary syndrome.
Either
a) Myocardial infarction type 1 according to the Third Universal definition of myocardial infarction
or
b) Unstable angina

Exclusion Criteria

1. Elevation of troponin and/or ECG changes not thought to be due to an ACS
2. End stage renal failure (eGFR<15 ml/min/m2) OR is receiving OR planned to receive renal replacement therapy
3. Patient is not resident in New Zealand

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary composite endpoint of death, recurrent ACS, revascularisation, and readmission for a cardiac cause.<br><br>This is assessed via linkage of data with the All NZ Acute Coronary Syndrome Quality Improvement (ANZACS-QI) database (which will include outcomes) via encrypted patient national health identifier number.[ 1, 3, and 5 years after baseline assessment]

Secondary Outcome Measures

Name	Time	Method
Whole-genome array-based genotyping will be performed on the DNA samples of participants to search for genetic variants affecting the risk of acute coronary syndromes.[ 3 years after baseline assessment]