PrediCT - Predisposition to Childhood Tumors
Not Applicable
Completed
- Conditions
- <p>Pediatric cancer/neoplasms</p>10068775
- Registration Number
- NL-OMON20548
- Lead Sponsor
- Princes Máxima Center for pediatric oncology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 843
Inclusion Criteria
- Children (age < 19 years) newly diagnosed with cancer or neoplasms at the Princess Máxima Center - Written informed consent (by patient when aged 16 years or older, by patient and parent(s) when aged 12-16 years, by parent(s) when younger than 12 years)
Exclusion Criteria
- Patients and/or their parents who don't want to know the results of the DNA test (pediatric cancer gene panel analysis)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Endpoint of this study is determining the performance of a ‘genotype first approach’ in diagnostics of genetic predisposition in children with cancer (unselected for type of tumor), compared to the current ‘phenotype first approach’. We will evaluate the number of identified pediatric cancer predisposition syndromes (CPSs) by the genotype first approach and the phenotype first approach and will focus on discrepancies in diagnoses between these two approaches. Pediatric cancer predisposition syndromes are defined as clinical diagnosis (made by a clinical geneticist) and/or molecular diagnosis (based on targeted tests or WES CPS panel).</p><br>
- Secondary Outcome Measures
Name Time Method