The impact of genetic predisposition in pediatric renal cancer: genotypic and phenotypic characterizatio
Completed
- Conditions
- kidney tumorsRenal tumors1002766410038364
- Registration Number
- NL-OMON46432
- Lead Sponsor
- Prinses Máxima Centrum voor Kinderoncologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
- All patients diagnosed with and/or treated for a renal tumor in the Princess Máxima Center.
- Additional patients with rare renal tumors may be included from the International Society of Pediatric Oncology (SIOP) 2001 database.
Exclusion Criteria
- Previously diagnosed cancer predisposition syndrome associated with the renal tumor
NB: These patients will not be included in whole exome sequencing, but will be registered in the WES-KidTs database.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Frequency of known and novel genetic causes of pediatric renal cancer.</p><br>
- Secondary Outcome Measures
Name Time Method <p>To structurally document phenotypic characteristics of children with renal<br /><br>cancer, to optimize genetic counseling and surveillance, and contribute to a<br /><br>better detection of pediatric renal cancer predisposition.</p><br>